UniProt ID | PUF68_DROME | |
---|---|---|
UniProt AC | Q8T6B9 | |
Protein Name | Poly(U)-binding-splicing factor half pint {ECO:0000303|PubMed:11879639} | |
Gene Name | hfp {ECO:0000303|PubMed:11879639, ECO:0000312|FlyBase:FBgn0028577} | |
Organism | Drosophila melanogaster (Fruit fly). | |
Sequence Length | 637 | |
Subcellular Localization | Nucleus . | |
Protein Description | Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq.. | |
Protein Sequence | MGSNDRASRSPRSDDQREISDMPATKRTRSDSGKSTDSKIPYLSQPLYDLKQTGDVKFGPGTRSALLGLLGGALPKLSSEQHDLVSKAKKYAMEQSIKMVLMKQTLAHQQQQLATQRTQVQRQQALALMCRVYVGSISFELKEDTIRVAFTPFGPIKSINMSWDPITQKHKGFAFVEYEIPEGAQLALEQMNGALMGGRNIKVGRPSNMPQAQQVIDEVQEEAKSFNRIYVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTHKGYGFIEYANKQAMDEAIASMNLFDLGGQLLRVGRSITPPNALACPTTNSTMPTAAAVAAAAATAKIQALDAVASNAVLGLSQNTPVMAAGAVVTKVGAMPVVSAATSAAALHPALAQAAPALLPPGIFQAPTPVAPSLLGVPAGLQPLQAVVPTLPPPALLATPTLPMTVGGVGVGLVPTVATLAGAEASKGAAAAAALSAAANNAAVTAANLSENIKKAHEKQQEELQKKLMDEGDVQTLQQQENMSIKGQSARQLVMQRLMRPVDSRVIILRNMVGPEDVDETLQEEIQEECSKFGTVSRVIIFNEKQTENEDDDEAEIIVKIFVEFSAGAEAMRGKEALDGRFFGGRRVVAELYDQGIFDQGDLSG | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
3 | Phosphorylation | -----MGSNDRASRS -----CCCCCCCCCC | 33.97 | 30478224 | |
10 | Phosphorylation | SNDRASRSPRSDDQR CCCCCCCCCCCCCHH | 23.36 | 25749252 | |
13 | Phosphorylation | RASRSPRSDDQREIS CCCCCCCCCCHHHHC | 49.26 | 22817900 | |
30 | Phosphorylation | PATKRTRSDSGKSTD CCCCCCCCCCCCCCC | 35.20 | 12537569 | |
32 | Phosphorylation | TKRTRSDSGKSTDSK CCCCCCCCCCCCCCC | 49.74 | 21082442 | |
35 | Phosphorylation | TRSDSGKSTDSKIPY CCCCCCCCCCCCCCC | 40.76 | 21082442 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PUF68_DROME !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PUF68_DROME !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PUF68_DROME !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
AIMP2_DROME | CG12304 | physical | 14605208 | |
SINAL_DROME | sinah | physical | 14605208 | |
RM39_DROME | mRpL39 | physical | 14605208 | |
TRXR1_DROME | Trxr-1 | physical | 14605208 | |
CCNB_DROME | CycB | physical | 14605208 | |
ACT1_DROME | Act5C | physical | 14605208 | |
DDX6_DROME | me31B | physical | 14605208 | |
TF2AA_DROME | TfIIA-L | physical | 14605208 | |
CLH_DROME | Chc | physical | 14605208 | |
MYC_DROME | dm | genetic | 26074141 | |
OTU_DROME | otu | genetic | 11879639 | |
ERCC3_DROME | hay | genetic | 26074141 | |
ERCC3_DROME | hay | genetic | 20667914 | |
TRA2_DROME | tra2 | physical | 23880637 | |
ERCC3_DROME | hay | physical | 20667914 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-30, AND MASSSPECTROMETRY. |