TF2AA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2AA_DROME
• UniProt AC: P52654
• Protein Name: Transcription initiation factor IIA subunit 1
• Gene Name: TfIIA-L
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 366
• Subcellular Localization: Nucleus.
• Protein Description: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity..
• Protein Sequence: MALCQTSVLKVYHAVIEDVITNVRDAFLDEGVDEQVLQEMKQVWRNKLLASKAVELSPDSGDGSHPPPIVANNPKSHKAANAKAKKAAAATAVTSHQHIGGNSSMSSLVGLKSSAGMAAGSGIRNGLVPIKQEVNSQNPPPLHPTSAASMMQKQQQAASSGQGSIPIVATLDPNRIMPVNITLPSPAGSASSESRVLTIQVPASALQENQLTQILTAHLISSIMSLPTTLASSVLQQHVNAALSSANHQKTLAAAKQLDGALDSSDEDESEESDDNIDNDDDDDLDKDDDEDAEHEDAAEEEPLNSEDDVTDEDSAEMFDTDNVIVCQYDKITRSRNKWKFYLKDGIMNMRGKDYVFQKSNGDAEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
265	Phosphorylation	LDGALDSSDEDESEE HCCCCCCCCCCCCCC	44.69	-
306	Phosphorylation	AEEEPLNSEDDVTDE HHHCCCCCCCCCCCH	50.51	-
353	Acetylation	GIMNMRGKDYVFQKS CCCCCCCCCEEEECC	35.21	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
265	S	Phosphorylation	Kinase	TAF1	P51123	Uniprot
306	S	Phosphorylation	Kinase	TAF1	P51123	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2AA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2AA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VND_DROME	vnd	physical	14605208
PP11_DROME	Pp1alpha-96A	physical	14605208
RL22_DROME	RpL22	physical	14605208
RS8_DROME	RpS8	physical	14605208
DEAF1_DROME	Deaf1	physical	14605208
TAF4_DROME	Taf4	physical	8224849
T2AG_DROME	TfIIA-S	physical	7958898
TF2AA_DROME	TfIIA-L	physical	7958898

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.