DDX6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX6_DROME
• UniProt AC: P23128
• Protein Name: Putative ATP-dependent RNA helicase me31b
• Gene Name: me31B
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 459
• Subcellular Localization: Cytoplasm . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
• Protein Description: Unwinds RNA in an ATP-dependent fashion (Potential). Involved in germ cell formation..
• Protein Sequence: MMTEKLNSGHTNLTSKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLMGIFEKGWERPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTRELALQTSQICIELAKHLDIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVADMSHCRILVLDEADKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLMEELTLKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMAQAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHLGIAINLITYEDRFDLHRIEKELGTEIKPIPKVIDPALYVANVGASVGDTCNNSDLNNSANEEGNVSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MMTEKLNSGHTNLTS CCCCCCCCCCCCCCC	42.25	22817900
29	Phosphorylation	LQIAGNTSDDMGWKS EEECCCCCCCCCCCC	35.30	22817900
161	Phosphorylation	DIRVMVTTGGTILKD CEEEEEEECCCCCHH	23.39	21082442
164	Phosphorylation	VMVTTGGTILKDDIL EEEEECCCCCHHHHH	25.20	21082442
412	Acetylation	FDLHRIEKELGTEIK CCHHHHHHHHCCCCC	56.73	21791702
441	Phosphorylation	VGASVGDTCNNSDLN CCCCCCCCCCCCCCC	15.94	19429919
445	Phosphorylation	VGDTCNNSDLNNSAN CCCCCCCCCCCCCCC	29.50	19429919
450	Phosphorylation	NNSDLNNSANEEGNV CCCCCCCCCCCCCCC	31.25	19285948
458	Phosphorylation	ANEEGNVSK------ CCCCCCCCC------	36.33	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSL2_DROME	msl-2	physical	23788626
CUP_DROME	cup	physical	14723848
GRK_DROME	grk	physical	23213441
EXU_DROME	exu	physical	14723848
EXU_DROME	exu	physical	11546740
NANOS_DROME	nos	physical	21081899
IF4E_DROME	eIF-4E	physical	14723848

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8; SER-29 AND SER-450,AND MASS SPECTROMETRY.
PubMed: 18327897