IF5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5_DROME
• UniProt AC: Q9VXK6
• Protein Name: Eukaryotic translation initiation factor 5
• Gene Name: eIF5
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 464
• Protein Description: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity)..
• Protein Sequence: MATVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLLKVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGTNQASQTEAEISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAKGMTISDDYDKTEKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKNRPLLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEEDNYVSSAGQRGGQRVVQRGIPRAVAGDEDDEDDVNIDDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ATVNVNRSVTDIFYR CEEECCCHHHHHHHH	24.94	19429919
11	Phosphorylation	VNVNRSVTDIFYRYK EECCCHHHHHHHHHH	25.32	19429919
156	Phosphorylation	LNPAAQGSSLTEGKR CCCCCCCCCCCHHHH	15.30	19429919
157	Phosphorylation	NPAAQGSSLTEGKRS CCCCCCCCCCHHHHH	46.25	19429919
159	Phosphorylation	AAQGSSLTEGKRSRK CCCCCCCCHHHHHHH	44.64	19429919
187	Phosphorylation	NNSLANNSGGESDGG CCHHCCCCCCCCCCC	48.24	22817900
191	Phosphorylation	ANNSGGESDGGNGTN CCCCCCCCCCCCCCC	44.84	19060867
197	Phosphorylation	ESDGGNGTNQASQTE CCCCCCCCCCCHHHH	28.32	29892262
201	Phosphorylation	GNGTNQASQTEAEIS CCCCCCCHHHHHHHH	28.06	21082442
203	Phosphorylation	GTNQASQTEAEISAA CCCCCHHHHHHHHHH	34.37	21082442
250	Phosphorylation	GAKGMTISDDYDKTE CCCCCCCCCCCCCHH	18.44	19429919
253	Phosphorylation	GMTISDDYDKTEKER CCCCCCCCCCHHHHH	25.08	19429919
412	Phosphorylation	LKNAEEESSESEEEE ECCCCHHCCCCCCCC	42.56	19429919
413	Phosphorylation	KNAEEESSESEEEED CCCCHHCCCCCCCCC	48.71	19429919
415	Phosphorylation	AEEESSESEEEEDDE CCHHCCCCCCCCCCC	52.86	19429919
423	Phosphorylation	EEEEDDESEEDNYVS CCCCCCCCHHHHCHH	53.96	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF2B_DROME	eIF-2beta	physical	17409115

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-412; SER-413 ANDSER-415, AND MASS SPECTROMETRY.
PubMed: 18327897