IF2B_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF2B_DROME
• UniProt AC: P41375
• Protein Name: Eukaryotic translation initiation factor 2 subunit 2
• Gene Name: eIF2beta {ECO:0000312|FlyBase:FBgn0004926}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 312
• Protein Description: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region..
• Protein Sequence: MDAEDGFDPTLLKKKKKKKTTFDLDAALGLEDDTKKEDPQDEASAEGGAAAEEDNLDLESFGKKKKKKKKPFNMDEIEAAIPSFGGDDVAASEEPEEEEINLDMDFSMAKKKKKSKKKELDELFADQADDDKSEDKENDEDNSSTWFGSDRDYTYDELLKRVFEIILDKNPDMAAGRKPKFVMRPPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGNQQLIIKGRFQPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGFQAVTGKRAAIRAKTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	EDPQDEASAEGGAAA CCCCHHHHHCCCHHH	25.46	19429919
133	Phosphorylation	DQADDDKSEDKENDE HHCCCCCCCCCCCCC	59.01	21082442
143	Phosphorylation	KENDEDNSSTWFGSD CCCCCCCCCCCCCCC	41.28	19429919
144	Phosphorylation	ENDEDNSSTWFGSDR CCCCCCCCCCCCCCC	35.59	19429919
145	Phosphorylation	NDEDNSSTWFGSDRD CCCCCCCCCCCCCCC	25.32	19429919
244	Acetylation	IKGRFQPKQIENVLR EEECCCHHHHHHHHH	53.80	21791702
265	Phosphorylation	VTCHTCRSPETILQK HCCCCCCCHHHHHCC	29.27	19429919
268	Phosphorylation	HTCRSPETILQKDTR CCCCCHHHHHCCCCE	30.30	19429919
286	Phosphorylation	LQCESCGSRCSVASI EEECCCCCCEEHHHH	34.15	21082442
289	Phosphorylation	ESCGSRCSVASIKSG CCCCCCEEHHHHHHC	21.43	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF2B_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF2B_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF2B_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFS1_DROME	CG12264	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133 AND THR-145, ANDMASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, AND MASSSPECTROMETRY.
PubMed: 17372656