COPB2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPB2_DROME
• UniProt AC: O62621
• Protein Name: Coatomer subunit beta'
• Gene Name: beta'COP {ECO:0000312|FlyBase:FBgn0025724}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 914
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)..
• Protein Sequence: MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYHGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTYRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQVNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKAFGSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWETLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLGEVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVISFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFDLALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQLLEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREKLGKVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPLNSERHPLQELFAAEQGAAGQHLEEKVKPAYVPAQAVVSSSQVAEPTSAADDDDDLDLEIDGITLDDNIDTTDVNLDDDFLSDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
629	Acetylation	RVAHFLEKQGFKSQA HHHHHHHHCCCCCCE	58.84	21791702
666	Phosphorylation	ALKLARESENSQKWS HHHHHHHCCCHHHHH	36.20	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPB2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPB2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPB2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.