SALM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SALM_DROME
• UniProt AC: P39770
• Protein Name: Homeotic protein spalt-major
• Gene Name: salm
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1365
• Subcellular Localization: Nucleus .
• Protein Description: Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene..
• Protein Sequence: MKNHLSNVLCAMRSDFKDNHQETINKMIQFGTVKYGIVKQLKDRARSADKDIGSDQEENGGCSPLTTATTTASPSRSPEPEEEQPEEQSTSEQSIPEQSTPDHQLENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHLINAGVPLRESSGSPAESLKRRREHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETFRNRAVKYMSEWNEDRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
641	Sumoylation	LPLEVRIKEERVEEQ CCCEEEEEHHHHHHH	42.85	-
739	Phosphorylation	FTTAKMLSPEHHSPV CCCCCCCCCCCCCCC	25.41	18327897
744	Phosphorylation	MLSPEHHSPVRSPAG CCCCCCCCCCCCCCC	27.31	18327897
1076	Phosphorylation	RSSSPARSEASQGAL CCCCCCCCHHHCCCC	39.35	18327897
1079	Phosphorylation	SPARSEASQGALDLT CCCCCHHHCCCCCCC	25.70	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SALM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SALM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SALM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SALA_DROME	sala	genetic	16453821
GIL_DROME	aos	genetic	11171397
KNIR_DROME	kni	genetic	9753669

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739; SER-744; SER-1076AND SER-1079, AND MASS SPECTROMETRY.
PubMed: 18327897