SOG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOG_DROME
• UniProt AC: Q24025
• Protein Name: Dorsal-ventral patterning protein Sog
• Gene Name: sog
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1038
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein . Cell membrane ; Single-pass type I membrane protein . Secreted .
• Protein Description: Putative negative growth factor. [PubMed: 7958919 Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg]
• Protein Sequence: MANKLRKSNAIEWATATGTVPLLERSCCHSEDAALEPQASKTSHREQAPILRHLSQLSHLLIIAGLLIVCLAGVTEGRRHAPLMFEESDTGRRSNRPAVTECQFGKVLRELGSTWYADLGPPFGVMYCIKCECVAIPKKRRIVARVQCRNIKNECPPAKCDDPISLPGKCCKTCPGDRNDTDVALDVPVPNEEEERNMKHYAALLTGRTSYFLKGEEMKSMYTTYNPQNVVATARFLFHKKNLYYSFYTSSRIGRPRAIQFVDDAGVILEEHQLETTLAGTLSVYQNATGKICGVWRRVPRDYKRILRDDRLHVVLLWGNKQQAELALAGKVAKYTALQTELFSSLLEAPLPDGKTDPQLAGAGGTAIVSTSSGAASSMHLTLVFNGVFGAEEYADAALSVKIELAERKEVIFDEIPRVRKPSAEINVLELSSPISIQNLRLMSRGKLLLTVESKKYPHLRIQGHIVTRASCEIFQTLLAPHSAESSTKSSGLAWVYLNTDGSLAYNIETEHVNTRDRPNISLIEEQGKRKAKLEDLTPSFNFNQAIGSVEKLGPKVLESLYAGELGVNVATEHETSLIRGRLVPRPVADARDSAEPILLKRQEHTDAQNPHAVGMAWMSIDNECNLHYEVTLNGVPAQDLQLYLEEKPIEAIGAPVTRKLLEEFNGSYLEGFFLSMPSAELIKLEMSVCYLEVHSKHSKQLLLRGKLKSTKVPGHCFPVYTDNNVPVPGDHNDNHLVNGETKCFHSGRFYNESEQWRSAQDSCQMCACLRGQSSCEVIKCPALKCKSTEQLLQRDGECCPSCVPKKEAADYSAQSSPATNATDLLQQRRGCRLGEQFHPAGASWHPFLPPNGFDTCTTCSCDPLTLEIRCPRLVCPPLQCSEKLAYRPDKKACCKICPEGKQSSSNGHKTTPNNPNVLQDQAMQRSPSHSAEEVLANGGCKVVNKVYENGQEWHPILMSHGEQKCIKCRCKDSKVNCDRKRCSRSTCQQQTRVTSKRRLFEKPDAAAPAIDECCSTQCRRSRRHHKRQPHHQQRSSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	N-linked_Glycosylation	KTCPGDRNDTDVALD CCCCCCCCCCCEEEE	62.36	-
287	N-linked_Glycosylation	GTLSVYQNATGKICG HHEEEECCCCCCCCC	23.06	-
520	N-linked_Glycosylation	VNTRDRPNISLIEEQ CCCCCCCCCCHHHHC	37.06	-
666	N-linked_Glycosylation	RKLLEEFNGSYLEGF HHHHHHHCCCHHEEE	41.61	-
752	N-linked_Glycosylation	FHSGRFYNESEQWRS EECCCCCCCCHHHHC	43.54	-
821	N-linked_Glycosylation	AQSSPATNATDLLQQ CCCCCCCCHHHHHHH	42.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSG_DROME	tsg	genetic	21839924
ITA1_DROME	mew	genetic	12835400
DECA_DROME	dpp	genetic	12835400
DECA_DROME	dpp	genetic	22745309
MAD_DROME	Mad	genetic	11585808
CO4A1_DROME	Cg25C	genetic	12835400
ITA3_DROME	scb	genetic	12835400
SMUF1_DROME	lack	genetic	11703946
60A_DROME	gbb	genetic	12835400
RHOM_DROME	rho	genetic	12835400
LAMA_DROME	LanA	genetic	12835400
FAF_DROME	faf	genetic	22745309
ITBX_DROME	mys	genetic	12835400
DECA_DROME	dpp	physical	11260716
TLD_DROME	tld	physical	25642644

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.