TLD_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLD_DROME
• UniProt AC: P25723
• Protein Name: Dorsal-ventral patterning protein tolloid
• Gene Name: tld
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1067
• Protein Description: Required for normal dorsal development. TLD may interact physically with DPP-C protein..
• Protein Sequence: MKGMRLMPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGEDFDAVTPFPGYLKSMYSSETGSDHLLPPSRLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
176	N-linked_Glycosylation	QAMRHWENFTCIKFV HHHHHHHCEEEEEEE	32.13	-
441	N-linked_Glycosylation	LVRRICGNVSGEVIT HHHHHHCCCCCCEEE	21.99	-
543	N-linked_Glycosylation	FVEIRDGNHSDSRLI EEEEECCCCCCCCCC	35.46	-
644	N-linked_Glycosylation	VVDATKSNGSLYSPS EEEECCCCCCCCCCC	45.70	-
677	N-linked_Glycosylation	PNHAVFLNFSHFDLE CCEEEEEECCEECCC	25.55	-
791	N-linked_Glycosylation	TLAENGHNCTETRCK EEECCCCCCCCCEEE	35.49	-
864	N-linked_Glycosylation	IYDGRSENSSTLGIY EECCCCCCCCEEEEE	42.37	-
918	N-linked_Glycosylation	GGYLRATNHSQTFYS CCEEEECCCCCCCCC	31.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLD_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLD_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLD_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOG_DROME	sog	genetic	1618130
SOG_DROME	sog	physical	10769238
SOG_DROME	sog	physical	12925593
SOG_DROME	sog	physical	15797386
SOG_DROME	sog	physical	21839924
SOG_DROME	sog	physical	9363950
INHB_DROME	Actbeta	physical	17119021

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.