INHB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INHB_DROME
• UniProt AC: O61643
• Protein Name: Inhibin beta chain
• Gene Name: Actbeta
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 946
• Subcellular Localization: Secreted .
• Protein Description: Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain..
• Protein Sequence: MRFAFDSNHSQSGAPFKGSRCFFNCQCICCRQGCCVVVVKCCCCFNLNCCNSLGSRKSFPQPAAMRKKVADLEVLRVSRFVAVILVLARWVTAVATLLTSCILLDIFSVPGQSGVADRSQASSRTVHVSVPTTPNETPSSTSETKLKLLYGYTSYDINNDQQVKSNNLCRVLCKSRNRKRQRRRRRRRNHRRRRHRYTKRLHHLMQDNMSGFEQRLNFSDAKCQSLETNYGTNYDLVQGGKLFSQSERSLLVSPLREIEAPWPAIHGSMRNCSKIKRNRANLIWLLIGLVWFEVKLINCNGISSSNYYASNLESHKGCTLCHESGKPNIYTDKDNPHTDYNIYNKYHSNNNFNKKTNQPHNNIAPSDEVRLESIKRQILTKLGLSHKPNVSHPLPKQFIWETIYRVDGGRMIPNNAFGSSGKNLDQKTIKLRAFASPGSHLFNGRGGRTDQRSERDPSHHKYRSPFDFTFNISKNNVYGKVLRNRSLERIDKKNSFLNGWTENRQLKINSQIASMPIELKSHHNSSPKELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDLPKMVVDECGCP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	N-linked_Glycosylation	LHHLMQDNMSGFEQR HHHHHHHCCCHHHHH	15.04	-
210	Phosphorylation	HLMQDNMSGFEQRLN HHHHHCCCHHHHHHC	46.73	30478224
217	N-linked_Glycosylation	SGFEQRLNFSDAKCQ CHHHHHHCCCHHHHH	36.24	-
225	Phosphorylation	FSDAKCQSLETNYGT CCHHHHHHCCCCCCC	37.33	22817900
228	Phosphorylation	AKCQSLETNYGTNYD HHHHHCCCCCCCCCE	38.75	22817900
271	N-linked_Glycosylation	AIHGSMRNCSKIKRN HHCCHHCCHHHHHHH	26.27	-
389	N-linked_Glycosylation	LGLSHKPNVSHPLPK HCCCCCCCCCCCCCC	53.37	-
471	N-linked_Glycosylation	SPFDFTFNISKNNVY CCCCEEEEECCCCEE	34.27	-
484	N-linked_Glycosylation	VYGKVLRNRSLERID EEHHHHCCCCHHHHH	33.46	-
542	N-linked_Glycosylation	VRKVNGINGTQMNEN CEEECCCCCCCCCHH	49.19	-
561	N-linked_Glycosylation	STYPIDINHSIDNKT CCCCCCCCCEECCCC	21.07	-
566	N-linked_Glycosylation	DINHSIDNKTHTGKN CCCCEECCCCCCCCC	49.83	-
732	N-linked_Glycosylation	FQLSTSINITEKGID EEECCCEECCCCCCC	34.59	-
804	N-linked_Glycosylation	QTSKLRGNSSDYLST ECCCCCCCCCCCCCC	31.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INHB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INHB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INHB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
7LESS_DROME	sev	genetic	18054857
TUTL_DROME	tutl	genetic	19906964

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.