dbPTM

UBX_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBX_DROME
UniProt AC	P83949
Protein Name	Homeotic protein ultrabithorax
Gene Name	Ubx
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	389
Subcellular Localization	Nucleus.
Protein Description	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor..
Protein Sequence	MNSYFEQASGFYGHPHQATGMAMGSGGHHDQTASAAAAAYRGFPLSLGMSPYANHHLQRTTQDSPYDASITAACNKIYGDGAGAYKQDCLNIKADAVNGYKDIWNTGGSNGGGGGGGGGGGGGAGGTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQGGHLDQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
127	Phosphorylation	GGGGAGGTGGAGNAN CCCCCCCCCCCCCCC	31.37	22817900
170	Phosphorylation	RVGGYLDTSGGSPVS CCCCEEECCCCCCCC	27.03	22817900
171	Phosphorylation	VGGYLDTSGGSPVSH CCCEEECCCCCCCCC	40.60	22817900
174	Phosphorylation	YLDTSGGSPVSHRGG EEECCCCCCCCCCCC	26.17	22817900
177	Phosphorylation	TSGGSPVSHRGGSAG CCCCCCCCCCCCCCC	15.73	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBX_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBX_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBX_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERM_DROME	term	physical	14605208
FZO_DROME	fzo	physical	14605208
1433E_DROME	14-3-3epsilon	physical	16455680
NOC_DROME	noc	physical	16455680
NRT_DROME	Nrt	physical	16455680
PSD11_DROME	Rpn6	physical	16455680
AL_DROME	al	physical	16455680
ARM_DROME	arm	physical	16455680
NCBP1_DROME	Cbp80	physical	16455680
DSH_DROME	dsh	physical	16455680
EF2_DROME	EF2	physical	16455680
PYG_DROME	GlyP	physical	16455680
HAIR_DROME	h	physical	16455680
HSP7D_DROME	Hsc70-4	physical	16455680
MIC60_DROME	CG6455	physical	16455680
OTU_DROME	otu	physical	16455680
RL22_DROME	RpL22	physical	16455680
RS13_DROME	RpS13	physical	16455680
EF1G_DROME	Ef1gamma	physical	16455680
CHDM_DROME	Mi-2	physical	16455680
YEMA_DROME	yem	physical	16455680
AL_DROME	al	genetic	16455680
ARM_DROME	arm	genetic	16455680
KZ_DROME	kz	genetic	10101174
CRN_DROME	crn	genetic	10101174
ZEST_DROME	z	genetic	3124114
ZEST_DROME	z	genetic	9560400
NOTCH_DROME	N	genetic	9832527
RB27C_DROME	Hrb27C	genetic	10101174
FL2D_DROME	fl(2)d	genetic	10101174
ASX_DROME	Asx	genetic	19956620
PCL_DROME	Pcl	genetic	6813190
EGFR_DROME	Egfr	genetic	16815386
VEIN_DROME	vn	genetic	16815386
GIL_DROME	aos	genetic	16815386
MED19_DROME	MED19	genetic	24786462
ASH1_DROME	ash1	genetic	8555105
HMPB_DROME	pb	genetic	16094438
HTH_DROME	hth	genetic	10395787
SUHW_DROME	su(Hw)	genetic	8375652
SUHW_DROME	su(Hw)	genetic	8913756
SUHW_DROME	su(Hw)	genetic	17737996
ABDA_DROME	abd-A	genetic	8670898
ABDA_DROME	abd-A	genetic	16971094
DL_DROME	Dl	genetic	16414040
STX1A_DROME	Syx1A	genetic	16815386
ASH2_DROME	ash2	genetic	8555105
RYK1_DROME	drl	genetic	16815386
NU301_DROME	E(bx)	genetic	12502740
ABDB_DROME	Abd-B	genetic	8670898
VIR_DROME	vir	genetic	10101174
GAGA_DROME	Trl	genetic	7935842
GAGA_DROME	Trl	genetic	12815073
GAGA_DROME	Trl	genetic	15063171
EXD_DROME	exd	physical	7846045
EXD_DROME	exd	physical	7915199
MAD_DROME	Mad	physical	25869471
SLP2_DROME	slp2	physical	25869471
TF2B_DROME	TfIIB	physical	25869471
SUH_DROME	Su(H)	physical	25869471
TSH_DROME	tsh	physical	25869471
APTE_DROME	ap	physical	25869471
MEF2_DROME	Mef2	physical	25869471
EVE_DROME	eve	physical	25869471
FKB12_DROME	FK506-bp2	physical	25242320
TWIST_DROME	twi	physical	25869471
DLL_DROME	Dll	physical	25869471
FOXF_DROME	bin	physical	25869471
MED19_DROME	MED19	physical	24786462
KNIR_DROME	kni	physical	25869471
7UP1_DROME	svp	physical	25869471
7UP2_DROME	svp	physical	25869471
EMS_DROME	ems	physical	25869471
SRP_DROME	srp	physical	25869471
TIN_DROME	tin	physical	25869471
BAGP_DROME	bap	physical	25869471
SLOU_DROME	slou	physical	25869471
PNT1_DROME	pnt	physical	25869471
PNT2_DROME	pnt	physical	25869471
MYOD_DROME	nau	physical	25869471
ZFH1_DROME	zfh1	physical	25869471
PANG1_DROME	pan	physical	25869471
PANG2_DROME	pan	physical	25869471
PNR_DROME	pnr	physical	25869471
COLL_DROME	kn	physical	25869471

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBX_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-170; SER-174 ANDSER-177, AND MASS SPECTROMETRY.	18327897 [Abstract]