dbPTM

KZ_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KZ_DROME
UniProt AC	O46072
Protein Name	Probable ATP-dependent RNA helicase kurz
Gene Name	kz
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1192
Subcellular Localization
Protein Description
Protein Sequence	MGKKVHNAKARQNPQTIVDNSAVKKIQIDVDAVAGGNQVGYDEANALVLPSEKRATKIKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASVIKSWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYDVALSELTPLWPPVDKKEPQRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
529	Phosphorylation	ETIDDAASTVEDPKE HCCCHHHHCCCCHHH	34.40	19429919
530	Phosphorylation	TIDDAASTVEDPKEL CCCHHHHCCCCHHHC	24.16	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KZ_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KZ_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KZ_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KZ_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-529 AND THR-530, ANDMASS SPECTROMETRY.	18327897 [Abstract]