dbPTM

NRT_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NRT_DROME
UniProt AC	P23654
Protein Name	Neurotactin
Gene Name	Nrt
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	846
Subcellular Localization	Membrane Single-pass type II membrane protein . Expressed in membranes during embryogenesis.
Protein Description	May mediate or modulate cell adhesion between embryonic cells during development..
Protein Sequence	MGELEEKETPPTETTAAQQEALEEPKETDKMLDKKEDAKEKTPSPQTSKPASPNAGKKSSPVAEKKIDDAELAKSKSGNGEEIIDIPAENGTKPDSADDKKISKEEREVKPKKIPIGGLKLPGFFMKNKPKADGDGAEGELLEKEKEEDKDKEANGDAATGSGKDEQKSRPGLGERLRSFFARKPSAEKEKKQLVNGDADAKSEATAEATPAEDASDAPPKRGLLNAIKLPIANMIPKKKSNDDVELGLGKAGLASMETLDDSLKDQDTVDRAPVKTNGTEELKGELKDEKLAAEEKLAAEEEEQNRPVSLLTRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLIGAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECADIQCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIVPRYARVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	ALEEPKETDKMLDKK HHHCCHHHHHHHHHH	47.23	-
42	Phosphorylation	KEDAKEKTPSPQTSK HHHHHHCCCCCCCCC	30.04	22817900
44	Phosphorylation	DAKEKTPSPQTSKPA HHHHCCCCCCCCCCC	34.57	22817900
47	Phosphorylation	EKTPSPQTSKPASPN HCCCCCCCCCCCCCC	41.94	22817900
48	Phosphorylation	KTPSPQTSKPASPNA CCCCCCCCCCCCCCC	31.25	22817900
52	Phosphorylation	PQTSKPASPNAGKKS CCCCCCCCCCCCCCC	27.49	22817900
60	Phosphorylation	PNAGKKSSPVAEKKI CCCCCCCCCCHHHHC	32.07	27794539
75	Phosphorylation	DDAELAKSKSGNGEE CHHHHHHCCCCCCCE	26.84	-
77	Phosphorylation	AELAKSKSGNGEEII HHHHHCCCCCCCEEE	44.58	18327897
103	Phosphorylation	SADDKKISKEEREVK CCCCCCCCHHHHCCC	42.78	-
169	Phosphorylation	SGKDEQKSRPGLGER CCCCHHHCCCCHHHH	43.32	-
186	Phosphorylation	SFFARKPSAEKEKKQ HHHHCCCCCHHHHHH	52.69	-
203	Phosphorylation	NGDADAKSEATAEAT CCCCCHHHHHCHHCC	33.90	22817900
206	Phosphorylation	ADAKSEATAEATPAE CCHHHHHCHHCCCCH	22.45	22817900
216	Phosphorylation	ATPAEDASDAPPKRG CCCCHHCCCCCCCCC	46.78	27794539
241	Phosphorylation	NMIPKKKSNDDVELG HCCCCCCCCCCCCCC	55.13	27794539
256	Phosphorylation	LGKAGLASMETLDDS CCHHHHHHHHHHCHH	23.38	22817900
259	Phosphorylation	AGLASMETLDDSLKD HHHHHHHHHCHHHCC	27.18	22817900
263	Phosphorylation	SMETLDDSLKDQDTV HHHHHCHHHCCCCCC	36.66	22817900
269	Phosphorylation	DSLKDQDTVDRAPVK HHHCCCCCCCCCCCC	20.76	22817900
410	N-linked_Glycosylation	DDINMCWNDTLQTHN HHHCCHHHHHHHHCC	27.71	-
417	N-linked_Glycosylation	NDTLQTHNSSVVCTQ HHHHHHCCCEEEEEE	39.09	-
428	N-linked_Glycosylation	VCTQRLGNGTTVGDE EEEEECCCCCEECCC	49.59	-
611	Phosphorylation	QCLREASSERLWAAT HHHHHHCCCCCEEEC	33.51	22668510
636	N-linked_Glycosylation	LPQPQEANASGSRHE CCCCCCCCCCCCCCE	33.61	-
691	N-linked_Glycosylation	KLRELHANWTREEVR HHHHHHHCCCHHHHH	29.88	-
720	N-linked_Glycosylation	DEVIEKYNASSYASL HHHHHHHCCCCHHHH	44.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
28	T	Phosphorylation	Kinase	PKC	-	Uniprot
75	S	Phosphorylation	Kinase	PKC	-	Uniprot
103	S	Phosphorylation	Kinase	PKC	-	Uniprot
169	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NRT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NRT_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS27A_DROME	RpS27A	physical	24292889
NRG_DROME	Nrg	genetic	9491984
ABL_DROME	Abl	genetic	12783792
AMAL_DROME	Ama	physical	10970840
AMAL_DROME	Ama	physical	12783792

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NRT_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-42; SER-44; THR-47;SER-48; SER-52; SER-77; SER-203; THR-206; SER-256; THR-259; SER-263AND THR-269, AND MASS SPECTROMETRY.	18327897 [Abstract]