NRT_DROME - dbPTM
NRT_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NRT_DROME
UniProt AC P23654
Protein Name Neurotactin
Gene Name Nrt
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 846
Subcellular Localization Membrane
Single-pass type II membrane protein . Expressed in membranes during embryogenesis.
Protein Description May mediate or modulate cell adhesion between embryonic cells during development..
Protein Sequence MGELEEKETPPTETTAAQQEALEEPKETDKMLDKKEDAKEKTPSPQTSKPASPNAGKKSSPVAEKKIDDAELAKSKSGNGEEIIDIPAENGTKPDSADDKKISKEEREVKPKKIPIGGLKLPGFFMKNKPKADGDGAEGELLEKEKEEDKDKEANGDAATGSGKDEQKSRPGLGERLRSFFARKPSAEKEKKQLVNGDADAKSEATAEATPAEDASDAPPKRGLLNAIKLPIANMIPKKKSNDDVELGLGKAGLASMETLDDSLKDQDTVDRAPVKTNGTEELKGELKDEKLAAEEKLAAEEEEQNRPVSLLTRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLIGAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECADIQCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIVPRYARVD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationALEEPKETDKMLDKK
HHHCCHHHHHHHHHH
47.23-
42PhosphorylationKEDAKEKTPSPQTSK
HHHHHHCCCCCCCCC
30.0422817900
44PhosphorylationDAKEKTPSPQTSKPA
HHHHCCCCCCCCCCC
34.5722817900
47PhosphorylationEKTPSPQTSKPASPN
HCCCCCCCCCCCCCC
41.9422817900
48PhosphorylationKTPSPQTSKPASPNA
CCCCCCCCCCCCCCC
31.2522817900
52PhosphorylationPQTSKPASPNAGKKS
CCCCCCCCCCCCCCC
27.4922817900
60PhosphorylationPNAGKKSSPVAEKKI
CCCCCCCCCCHHHHC
32.0727794539
75PhosphorylationDDAELAKSKSGNGEE
CHHHHHHCCCCCCCE
26.84-
77PhosphorylationAELAKSKSGNGEEII
HHHHHCCCCCCCEEE
44.5818327897
103PhosphorylationSADDKKISKEEREVK
CCCCCCCCHHHHCCC
42.78-
169PhosphorylationSGKDEQKSRPGLGER
CCCCHHHCCCCHHHH
43.32-
186PhosphorylationSFFARKPSAEKEKKQ
HHHHCCCCCHHHHHH
52.69-
203PhosphorylationNGDADAKSEATAEAT
CCCCCHHHHHCHHCC
33.9022817900
206PhosphorylationADAKSEATAEATPAE
CCHHHHHCHHCCCCH
22.4522817900
216PhosphorylationATPAEDASDAPPKRG
CCCCHHCCCCCCCCC
46.7827794539
241PhosphorylationNMIPKKKSNDDVELG
HCCCCCCCCCCCCCC
55.1327794539
256PhosphorylationLGKAGLASMETLDDS
CCHHHHHHHHHHCHH
23.3822817900
259PhosphorylationAGLASMETLDDSLKD
HHHHHHHHHCHHHCC
27.1822817900
263PhosphorylationSMETLDDSLKDQDTV
HHHHHCHHHCCCCCC
36.6622817900
269PhosphorylationDSLKDQDTVDRAPVK
HHHCCCCCCCCCCCC
20.7622817900
410N-linked_GlycosylationDDINMCWNDTLQTHN
HHHCCHHHHHHHHCC
27.71-
417N-linked_GlycosylationNDTLQTHNSSVVCTQ
HHHHHHCCCEEEEEE
39.09-
428N-linked_GlycosylationVCTQRLGNGTTVGDE
EEEEECCCCCEECCC
49.59-
611PhosphorylationQCLREASSERLWAAT
HHHHHHCCCCCEEEC
33.5122668510
636N-linked_GlycosylationLPQPQEANASGSRHE
CCCCCCCCCCCCCCE
33.61-
691N-linked_GlycosylationKLRELHANWTREEVR
HHHHHHHCCCHHHHH
29.88-
720N-linked_GlycosylationDEVIEKYNASSYASL
HHHHHHHCCCCHHHH
44.40-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
28TPhosphorylationKinasePKC-Uniprot
75SPhosphorylationKinasePKC-Uniprot
103SPhosphorylationKinasePKC-Uniprot
169SPhosphorylationKinasePKC-Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NRT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NRT_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RS27A_DROMERpS27Aphysical
24292889
NRG_DROMENrggenetic
9491984
ABL_DROMEAblgenetic
12783792
AMAL_DROMEAmaphysical
10970840
AMAL_DROMEAmaphysical
12783792

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NRT_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-42; SER-44; THR-47;SER-48; SER-52; SER-77; SER-203; THR-206; SER-256; THR-259; SER-263AND THR-269, AND MASS SPECTROMETRY.

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