| UniProt ID | PCL_DROME | |
|---|---|---|
| UniProt AC | Q24459 | |
| Protein Name | Polycomb protein Pcl | |
| Gene Name | Pcl | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1043 | |
| Subcellular Localization | Nucleus . Chromosome . Associated with chromatin. Colocalizes with many PcG sites on polytene chromosomes. It also associates with many unique sites on polytene chromosomes. | |
| Protein Description | Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. Required for the correct spatial expression of the homeotic genes of the Antennapedia and Bithorax complexes.. | |
| Protein Sequence | MMNNHFHLQHDHPPQNVAHPFMQQPSTAVPSAPPATYGYLAQPAGQQPQWMTTTYQILPPSVGPATVAKRYYATTGPQTTHPTHPSTIQITNSFAQQSTPPKQQAATSCSPFKANNIRIISTAPSVYSLNKPPQEAHSTYAPVQSYYLPSGGGQTAGQINLLAASGTGKQLQPPPLVPVTNSTSPPSTVVLDRINICINNHYTETPTSLSSSLTTAQQPSPIIPAIQHKAILPLIDSSTADSSSCSSSSVSSSSYSGTATTSAAVVIVDEPDSTTTTPQTPPTTPEAMSSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPPPAPPVAAPSPAVTYALQEDVFIKCNDGRFYLGTIIDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTESTNTSPSGPMCVACKRSDIEDVVEICERCGRGYHRGCTVEIVTGSGIWSCKRCAKPMKMQQPVSHKITKPAGICRQLPYHADKLSWDEKHRVNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMERLKQTLKDYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELPKRVPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGGDTATTAIGLLGN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 294 | Phosphorylation | AMSSPGKSSPSPPLL HHCCCCCCCCCCCCH | 54.09 | 19429919 | |
| 295 | Phosphorylation | MSSPGKSSPSPPLLA HCCCCCCCCCCCCHH | 32.65 | 19429919 | |
| 297 | Phosphorylation | SPGKSSPSPPLLATQ CCCCCCCCCCCHHHH | 40.89 | 19429919 | |
| 303 | Phosphorylation | PSPPLLATQSLLKGV CCCCCHHHHHHHHCH | 20.75 | 19429919 | |
| 305 | Phosphorylation | PPLLATQSLLKGVNS CCCHHHHHHHHCHHC | 31.17 | 19429919 | |
| 805 | Phosphorylation | SRNHCDLSSDENSSS CCCCCCCCCCCCCCC | 23.61 | 25749252 | |
| 806 | Phosphorylation | RNHCDLSSDENSSSS CCCCCCCCCCCCCCC | 57.13 | 22817900 | |
| 840 | Phosphorylation | NNPFLMATPKKASQG CCCCEEECCCCCCCC | 22.98 | 25749252 | |
| 966 | Phosphorylation | PSQSRRNSTSSTATS CCCCCCCCCCCCCCC | 28.05 | 21082442 | |
| 967 | Phosphorylation | SQSRRNSTSSTATSS CCCCCCCCCCCCCCC | 30.19 | 21082442 | |
| 976 | Phosphorylation | STATSSSSNGIGAPG CCCCCCCCCCCCCCC | 40.81 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCL_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCL_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCL_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SUZ12_DROME | Su(z)12 | physical | 12697833 | |
| EZ_DROME | E(z) | physical | 12697833 | |
| HDAC1_DROME | Rpd3 | physical | 12697833 | |
| PCL_DROME | Pcl | physical | 12697833 | |
| ESC_DROME | esc | physical | 12697833 | |
| EZ_DROME | E(z) | physical | 11571280 | |
| ESC_DROME | esc | genetic | 1346755 | |
| SIR2_DROME | Sir2 | genetic | 15498488 | |
| BRM_DROME | brm | genetic | 1346755 | |
| RUVB2_DROME | rept | genetic | 16816423 | |
| CORTO_DROME | corto | genetic | 11810228 | |
| DOT1L_DROME | gpp | genetic | 15371351 | |
| HSP7D_DROME | Hsc70-4 | genetic | 11274417 | |
| ESC_DROME | esc | physical | 25242320 | |
| ESC_DROME | esc | physical | 11571280 | |
| EZ_DROME | E(z) | physical | 25242320 | |
| CAF1_DROME | Caf1 | physical | 12697833 | |
| SUZ12_DROME | Su(z)12 | physical | 25242320 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-805 AND SER-806, ANDMASS SPECTROMETRY. | |
