YEMA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YEMA_DROME
• UniProt AC: P25992
• Protein Name: yemanuclein {ECO:0000312|FlyBase:FBgn0005596}
• Gene Name: yem {ECO:0000312|FlyBase:FBgn0005596}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1002
• Subcellular Localization: Nucleus, nucleoplasm. Chromosome. Chromosome, centromere, kinetochore. Abundant in the nucleoplasm. Only a fraction of the protein is associated with the chromosomes. Localizes to the chromosome arms and coexpresses with cid at the centromere.
• Protein Description: May play a key role in egg organization. May be a transcriptional regulator having a role in chromatin remodeling in concert with Hira, a histone chaperone. Involved in chromosome segregation by affecting kinetochores function in the first meiotic division..
• Protein Sequence: MSKGGEHKRVTLTSIIQGDAGFSRFGSNILEPDAASAAPDNSSKPTTKTAKCIRIKLDLFETDSNKYPEFNYSRLLYLEKKKTKKLKQVSTTNGSASTDPFADNDDDVARIVKELEAKYGNSYATGRGKSKKDDYRDIGMGYDESDSFIDNTEAYDEIIPEEAETLEGGFYINCGALEFKNLTKKSYTTRTDAIIKMPERSRKRMVSSSSESSSSSSGDDDENDDGNNEEDDESDSEDDSEENDESDSEDDSESESLEDEDSAATAKSSSKYKDNHQAKRAKVIVTGKSKPSSSSLTSGKKPPTKPITTSSSSNSPRPSTVEISDTEDGQDPIQTQPSSQLQSLPQSQAQAQALKKVVKTTTVKDMLKAKRDSFLKSQSGTAAVKGVGNGELKCVSTDVSSSDSSDMESEHGRADRQAGQHGKDGQENLRTADTLLPTTLDADIVTAVNSFKEAVKSRDMCGKKFNLDVKLSPLLLRVYEAVLCTDRNERNMVFSHIEYQLQLPKYYMLRKGKQVRAKEEKRKSTIMLEKLRRAVAVVMPKAVANYETELRTFAEQAAADVNSELPPKMPRKKFQWTSELRHLLYDVYQARWTSYAFLAKRKESLEEFINWYLKEKVVELWPPGWMRLDELQREITRYKNAKLKAKEKPKAPPASASPKPVGVVSAPEQMPPASSYLKAVEDPRSRGNSDTDSATSASSNSLKRKLKEMPKQTSKPPKKKVAKQVPLQPQLTPHPQFQLAPAATAAVSIPAISNNNNHLPHLDTLLSMPSTSAQAAALNAAAVAAASTVLDLASPSRKIDLNTSNNFYNLITAASLAASGNPSPHSGDGQAKVIVGARPSPHVINLDDYQCTSDILQTSKQLAATTTVITAISKAAQTTSVARESSSESDGVEIVGVFPASKPQKKVQSKPKNKTQNRGRSSLGAVGQVNGSLGYSANNMYIYNSPRTLGPVYDLTDPHIMKTMSNLKEMEKQFIQAAFSPNSVKGASGGMGSSAPSTPTRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
657	Phosphorylation	KAPPASASPKPVGVV CCCCCCCCCCCCEEE	30.84	21082442
665	Phosphorylation	PKPVGVVSAPEQMPP CCCCEEECCCCCCCC	35.38	22817900
685	Phosphorylation	KAVEDPRSRGNSDTD HHHCCCHHCCCCCCC	50.34	22817900
689	Phosphorylation	DPRSRGNSDTDSATS CCHHCCCCCCCCCHH	44.72	22817900
691	Phosphorylation	RSRGNSDTDSATSAS HHCCCCCCCCCHHCC	31.51	22817900
885	Phosphorylation	TTSVARESSSESDGV HCHHHHHCCCCCCCE	33.34	22817900
886	Phosphorylation	TSVARESSSESDGVE CHHHHHCCCCCCCEE	33.11	22817900
887	Phosphorylation	SVARESSSESDGVEI HHHHHCCCCCCCEEE	50.85	21080953
889	Phosphorylation	ARESSSESDGVEIVG HHHCCCCCCCEEEEE	41.43	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YEMA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YEMA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YEMA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIRA_DROME	Hira	physical	23408912

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-685; SER-689; SER-885;SER-886 AND SER-887, AND MASS SPECTROMETRY.
PubMed: 18327897