TWIST_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TWIST_DROME
• UniProt AC: P10627
• Protein Name: Protein twist
• Gene Name: twi
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 490
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the establishment and dorsoventral patterning of germ layers in the embryo..
• Protein Sequence: MMSARSVSPKVLLDISYKPTLPNIMELQNNVIKLIQVEQQAYMQSGYQLQHQQQHLHSHQHHQQHHQQQHAQYAPLPSEYAAYGITELEDTDYNIPSNEVLSTSSNQSAQSTSLELNNNNTSSNTNSSGNNPSGFDGQASSGSSWNEHGKRARSSGDYDCQTGGSLVMQPEHKKLIHQQQQQQQQHQQQIYVDYLPTTVDEVASAQSCPGVQSTCTSPQSHFDFPDEELPEHKAQVFLPLYNNQQQQSQQLQQQQPHQQSHAQMHFQNAYRQSFEGYEPANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTLPSDKLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLSYLFGVWRMEGDAQHQKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
325	Phosphorylation	ACLADDGSAGSLLDG HHCCCCCCCCCCCCC	36.13	22817900
328	Phosphorylation	ADDGSAGSLLDGSDA CCCCCCCCCCCCCCC	26.02	22817900
352	Phosphorylation	RRLKRKPSKTEETDE HHHCCCCCCCCCCCH	56.07	29892262
354	Phosphorylation	LKRKPSKTEETDEFS HCCCCCCCCCCCHHC	43.31	29892262
357	Phosphorylation	KPSKTEETDEFSNQR CCCCCCCCCHHCHHH	34.30	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TWIST_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TWIST_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TWIST_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOG_DROME	fog	genetic	9435280
WNTG_DROME	wg	genetic	11051548
WNTG_DROME	wg	genetic	15647321
DA_DROME	da	genetic	11688563
RAS1_DROME	Ras85D	genetic	11051548
DA_DROME	da	physical	22396663
DA_DROME	da	physical	11688563
DORS_DROME	dl	physical	9154833
DORS_DROME	dl	physical	9367978
TWIST_DROME	twi	physical	11688563
AKIRN_DROME	akirin	physical	22396663

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325 AND SER-328, ANDMASS SPECTROMETRY.
PubMed: 18327897