AKIRN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKIRN_DROME
• UniProt AC: Q9VS59
• Protein Name: Akirin
• Gene Name: akirin {ECO:0000303|PubMed:18066067}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 201
• Subcellular Localization: Nucleus .
• Protein Description: Required for embryonic development and for normal innate immune response. Effector of immune deficiency pathway (Imd) acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel). Not part of the Toll pathway..
• Protein Sequence: MACATLKRALDWESMNQRPPKRRRCNPFGQAGSNAGPASPSRDGPSTSAGLPHTPSNRFAKDSTEPSPFSESSLAKMSPDKMAESLCNEIKRLHKRKQLPITSSALERMQDSESSGSEMGPESPRRPDSPQNLMRHGEKALFTFKQVQLICESMIKERENQLRERYESVLTTKLAEQYDAFVKFTYDQIQRRYEAAPSYLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	GSNAGPASPSRDGPS CCCCCCCCCCCCCCC	26.92	22817900
41	Phosphorylation	NAGPASPSRDGPSTS CCCCCCCCCCCCCCC	40.27	22817900
67	Phosphorylation	AKDSTEPSPFSESSL CCCCCCCCCCCHHHH	32.14	18327897
78	Phosphorylation	ESSLAKMSPDKMAES HHHHHHCCHHHHHHH	29.28	22817900
115	Phosphorylation	RMQDSESSGSEMGPE HHHHCCCCCCCCCCC	42.14	22817900
123	Phosphorylation	GSEMGPESPRRPDSP CCCCCCCCCCCCCCH	27.17	22817900
129	Phosphorylation	ESPRRPDSPQNLMRH CCCCCCCCHHHHHHH	30.94	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKIRN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKIRN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKIRN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAP60_DROME	Bap60	physical	25180232
NFKB1_DROME	Rel	physical	25180232

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-41; SER-67;SER-123 AND SER-129, AND MASS SPECTROMETRY.
PubMed: 18327897