FOG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOG_DROME
• UniProt AC: P40795
• Protein Name: Protein folded gastrulation
• Gene Name: fog
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 730
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Coordinates cell shape changes during formation of the ventral furrow and invagination of the posterior midgut primordium, by inducing apical constriction of cells in spatially and temporally defined manners. Could function as a secreted signal to initiate apical constriction by acting as a ligand for an unidentified G protein-coupled receptor, which in turn activates the G protein alpha subunit encoded by concertina, in neighboring cells. Such an intracellular pathway would ultimately induce contraction of the apical actin-myosin network. In the ventral furrow, fog appears to ensure that all the cells initiate constriction within several minutes of each other. In the posterior midgut invagination, fog appears to direct the ordered progression of constriction initiations out from a central region and also to delimit the peripheral extent of this spreading..
• Protein Sequence: MSPPNCLLAVLALTVFIGANNALPITSRPIEGNVQRMVWEDWVNLDPEQRNLTKEKKITAKSIFTLPFRHCPQGHTLFNQLCIPQSNIDPTDLVKQELILAGGSNGSPPPPPIGDYDYGDDEESEEIVYDLSVIPTAMQDGLPPSVGTGDQALPSEDAPLKFNIFEKKFPTGTGEHEEMPLPPDMAAATYAKNISTTPETSTSITPTSTTTFAVPSVPSGEASNRIPGGVDLLAAPSDAFSTSTTLSMPTSNTTTTSNKDIGQVESIVLPADQEHDGLVHLVTSSLSDNDSDDSSTTLNGFNAEADLAQLLKVDAFWPVYDGSIELLPPLFSHRKVAPPLSADQDVKTKHAVDAAEKVGAELEEEVGEEEVTATDILPSEEDEYTTETATTTGDTTVAEASMDTSTATSTSGQSSPHPPEEPEIDERENRLVLIKSKVQPVQLTTTTSATATTAADVANSSSSTDRFHYQHFVEDESSTTTATPEPSSSTPGDPIEQSDMPASDNDNLMTNTIGGRGDDDDDGGHKATSEIHVQQELRLINELVKGKQRQQHQPQKQQLEPTSTEITSALTSTSTEDATTTTTTTTAYTNWSKVMPQLGQSTSETAATTETVATSGQVNEISLTATSASTEVKHFSITNRSYRNSKIIREDRLTVEPEGIVESAASTESAGTAATTPNSSSNPDGYTPLWWLPSIGWRLDRHLDGNGEDQSLLLRFFSTFRGSNTAATTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	NLDPEQRNLTKEKKI CCCHHHCCCCCCCCC	52.32	-
193	N-linked_Glycosylation	AAATYAKNISTTPET HHHHHEECCCCCCCC	25.85	-
252	N-linked_Glycosylation	TLSMPTSNTTTTSNK EEECCCCCCCCCCCC	43.87	-
289	N-linked_Glycosylation	VTSSLSDNDSDDSST EECCCCCCCCCCCCC	47.51	-
459	N-linked_Glycosylation	TTAADVANSSSSTDR CCHHHHHCCCCCCCC	42.12	-
590	N-linked_Glycosylation	TTTTAYTNWSKVMPQ EEEEEECCHHHHCHH	28.48	-
639	N-linked_Glycosylation	VKHFSITNRSYRNSK EEEEEEECCCHHCCE	29.27	-
678	N-linked_Glycosylation	GTAATTPNSSSNPDG CCCCCCCCCCCCCCC	53.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MARF_DROME	Marf	genetic	24101729
MTH1_DROME	mthl1	genetic	24222713
GNAL_DROME	cta	genetic	24101729

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.