CDK2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDK2_DROME
• UniProt AC: P23573
• Protein Name: Cyclin-dependent kinase 2 {ECO:0000312|FlyBase:FBgn0004107}
• Gene Name: Cdk2 {ECO:0000312|FlyBase:FBgn0004107}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 314
• Protein Description: Like Cdk1, could play a key role in the control of the eukaryotic cell cycle..
• Protein Sequence: MTTILDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPVDPNAGSASRLTRLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AEKIGEGTYGIVYKA HHHHCCCCEEEEEEE		-
19	Phosphorylation	EKIGEGTYGIVYKAR HHHCCCCEEEEEEEE		-
162	Phosphorylation	FNVPMRAYTHEVVTL CCCCCCCCCCCEEEE		19060867
163	Phosphorylation	NVPMRAYTHEVVTLW CCCCCCCCCCEEEEE		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDK2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDK2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDK2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERKA_DROME	rl	physical	14605208
KPC3_DROME	Pkc98E	physical	14605208
HRS_DROME	Hrs	physical	14605208
CCNC_DROME	CycC	physical	15575970
PP12_DROME	Pp1-87B	physical	15575970
DIMM_DROME	dimm	physical	15575970
DFD_DROME	Dfd	physical	15575970
ECR_DROME	EcR	physical	15575970
VTU2_DROME	Vm26Ab	physical	15575970
GUS_DROME	gus	physical	15575970
PGAM5_DROME	Pgam5	physical	15575970
FRY_DROME	fry	physical	15575970
RAD51_DROME	spn-A	physical	15575970
MED15_DROME	MED15	physical	15575970
GLIS2_DROME	sug	physical	15575970
STAT_DROME	Stat92E	physical	12586062
SXL_DROME	Sxl	physical	14605208
CCNE_DROME	CycE	physical	22036573
ORC1_DROME	Orc1	physical	16188887
ORC2_DROME	Orc2	physical	16188887
CCNE_DROME	CycE	physical	8156587
CCNE_DROME	CycE	physical	8980229
CCNA_DROME	CycA	physical	11027291

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.