RAD51_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAD51_DROME
• UniProt AC: Q27297
• Protein Name: DNA repair protein Rad51 homolog
• Gene Name: spn-A
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 336
• Subcellular Localization: Nucleus .
• Protein Description: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA (By similarity).; Spindle genes are required for each of the symmetry-breaking steps that generate polarity during egg axis formation; oocyte positioning at the posterior of the cyst to generate the first AP polarity and inhibition of gurken (grk) signaling to the follicle cell layer to polarize first the AP axis and then DV axis. May have a role in female meiosis..
• Protein Sequence: MEKLTNVQAQQEEEEEEGPLSVTKLIGGSITAKDIKLLQQASLHTVESVANATKKQLMAIPGLGGGKVEQIITEANKLVPLGFLSARTFYQMRADVVQLSTGSKELDKLLGGGIETGSITEIFGEFRCGKTQLCHTLAVTCQLPISQKGGEGKCMYIDTENTFRPERLAAIAQRYKLNESEVLDNVAFTRAHNSDQQTKLIQMAAGMLFESRYALLIVDSAMALYRSDYIGRGELAARQNHLGLFLRMLQRLADEFGVAVVITNQVTASLDGAPGMFDAKKPIGGHIMAHSSTTRLYLRKGKGETRICKIYDSPCLPESEAMFAILPDGIGDARES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	IKLLQQASLHTVESV HHHHHHHHCHHHHHH	19.15	22817900
85	Phosphorylation	LVPLGFLSARTFYQM CCCCCHHHHHHHHHH	17.28	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAD51_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAD51_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAD51_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DIMM_DROME	dimm	physical	15575970
BRCA2_DROME	Brca2	physical	15710747
POF_DROME	Pof	physical	15710747
MED26_DROME	MED26	physical	15710747
KMT5A_DROME	pr-set7	physical	15710747
TUD_DROME	tud	physical	15710747
ATPA_DROME	blw	physical	15710747
MYSA_DROME	Mhc	physical	15710747
RAD51_DROME	spn-A	physical	15710747
LOK_DROME	lok	genetic	27494704
BRCA2_DROME	Brca2	genetic	18266476
MCMR_DROME	rec	genetic	18957704

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.