BRCA2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRCA2_DROME
• UniProt AC: Q9W157
• Protein Name: Breast cancer type 2 susceptibility protein homolog {ECO:0000303|PubMed:17822964}
• Gene Name: Brca2 {ECO:0000312|FlyBase:FBgn0050169}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 971
• Subcellular Localization: Nucleus . Brca2 and spn-A/Rad51 become recruited to nuclear foci after DNA damage.
• Protein Description: Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint..
• Protein Sequence: MDQNGASGSHPNRLSQGRGAHARERGATVSAAANRSNIIDEMAKICEADRQTFAIARRTRGHERLAVDNSDFVAVEDLILSYAEPTPEDQVEMIMSDFCSSPTYAEDEDEPSHESEPWFRFRNKRIRTYSRKRDPKSHKAVQNEKRRGSSGLSVQRDLNTSFTSMACDFDASSQKIHEVLLNLSQYFSATATASGPTPVPSQIDLPTEARQDSGDECFNAELENLRDDLLQSGFTFEASFYENEHEQEGPGTMADTIYGDSMQSVPTTRLRLESGKRNVWSDADSTLKKADVEIAENKKLLMGQTQAKNVDIEENTNFILEGIPLSEWLTPMELPEISKDVIKHIPDKKLKLEPSSQKEQKSSKDSNASKVRGASKQSCDINTKNEGTTILDQPNAAEQENLLNDGELLEEFLFNDWQPMQCSNGPSTSKNAIQGPKENINSINLDDKEQPEKQTPNKSQTISSHQLNGIRKKSFKFIEVSEEMKIKGEEFVDKVVSGLYHFSHKCNLRTEEYSDNHSQVMESTQCAEFKSAPSKPIEILDGKETYNAIAKVDVGEINGKFSPLNNDTIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQSKETIQQNDYLVHQPNDKPTSVGLDTALKRSIESSEEMRSKASKLVVVDTTMREPHQPTLDPVCRDLNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSKATDQLNGWQPSDFPDVLPTSPNNEIHSINVENNKAVNTKTVSETEFFGFRTASNKGIVISENTKIKVAQFMSEFQAADASTDSNQPTVISEESRNIDAKFVDEAAAEDSANKPTFCNVQSLKNTSDIEHFKHDFFVEHSAKEEHPLCSQPLVRTPRRSQEIHSSLSQLAGKSPLDQATKKSVIARRNLLSLKRKRKIILSTETSTSCALPTMERFAPKPSSTSTPLADRDLNRSKDCTKNRQDAEDMSPICMQPKKSRRLGLSRSRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
924	Phosphorylation	ERFAPKPSSTSTPLA CHHCCCCCCCCCCCC	52.99	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRCA2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRCA2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRCA2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDS5B_HUMAN	PDS5B	physical	22293751
PDS5A_HUMAN	PDS5A	physical	22293751
RAD51_HUMAN	RAD51	physical	22293751
FACD2_HUMAN	FANCD2	physical	22293751
LOK_DROME	lok	genetic	18266476
NIPB_DROME	Nipped-B	physical	25588834
LAM0_DROME	Lam	physical	25588834
OTE_DROME	Ote	physical	25588834
LBR_DROME	LBR	physical	25588834
RAD51_DROME	spn-A	physical	25588834

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.