dbPTM

MED26_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MED26_DROME
UniProt AC	Q9V4F9
Protein Name	Mediator of RNA polymerase II transcription subunit 26
Gene Name	MED26
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1483
Subcellular Localization	Nucleus .
Protein Description	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA gene..
Protein Sequence	MNQIEIQELTTHLSQALDQNYDVVNMDAVLCVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRAKSLLKKWREMVGIQQTATENLAHPSQISSSQPALDLVKSPITSFITEPIAPSQQIVSDLHSNIDSAEPPLSGEHTLLHPNFSNLVNSIKDSDRHENIAITTLHTHKDRRHSHSIRSCHVASPQPIVIDHSVNSVINLTDDSTVKINEASVVIDIASDSDENDNNGSLNPKKLNSIVPAPLPIPSTPSSRQRKLKKEKRSKEREGQVATNTRFGAKASDGFQQAALTTDSEIFSLSNSSMSSIVSGDATSSYSQNKSRLNSNELTFTGRFKAVDHLFRSTESGKHKIDEYSAYDSNASCSRLSPSTVDEVKKAEHLFDAQLTNTTANQIPMSAVSIGYESNTRHEYLESDSPSQIPKRRGRKKGSKGVDALIAKESSSLSQQIFFGGSTVKKVKTTKELFNEIQSRKLSVSMQSSASNLSNSSTNRDLPSHTTFPRQTSSCSDTSMNSPHILETLSGSAIFASKIDDLGNTDSDTVTSDPSHDSNKSQEIKECTSLDSNSNSIQSLPLANNRENLIPTNVNDITTQLMHLIHSLNSPLSEIEIERVYQEKIIPCTCIVIEGVQGTLGESNNSTLDEQSYNAKISLNSKDNLSCHNQDNYSTSQRSVNGEVIDTQPKLVKSIFDLDFDDNDDPLYFIMDEIQKPIARADELKNNKSDTKNINFGASAQNASLNIIHFNDDAQQDNSNQERGKNETQNAIPAFTVHEDPDCLARQRFYIQTNKVTSFHINALHNYYIPNINGNWDSVESFTSFQSEHTIMDTMESYTVTNGADVVPKYGLLTSDRIRKDLSSLKSIKPYRVKNFTSLISPFLGVAKCLPTCRRARRRFKNFVNSSTANDKISNNFESLENMKTSFKNCNPLNVKIDGTTSAIYSHNENHVPMQVNTNVEQLPPSQSFSSNAISYNLLKLADDKVCHDGISDKSSNTGCQGNSPYSSSSSSSYSGRKEDQHIITKNLQNKNIQLNSRKSDMKRRKRIYLENDSKKKKHYRKRIKTAVNRTFSNLHRNLYSIDSENGMKNDYKNEYGNSNNEEYAIVQRPAGDGENCSNHIVLTIKKTPSKINSPANSMTAFSPPSTSDGANLQKSILDLRLEDTNISQSITEIPQKKDLSKTDRIVHQSRSSAYRRIFRKPDKSQTKFIDLDLKHLFHLKANSPCISANAKLHNKLFFPHELSRDNTSGIRERLINYSSSSSSSYDDDSEVENTSFLKKANVNKFSASNNRNLKTETETCAATAISEFKFESDEDSILTSLGDSDIDIQDEIQVINDKVDYCNDFQNNKMLESFNSIFVDSLRTNTKNASDNMGSSAHITSLESLKPENADAITRYCNNNNLGVNLSNELSNISAKPLKSFDSTMKLPSLGIEHCTGIKTSSDMASTNIAEKKLTRIQQFKEWHQVLQLRSYNNEPLIVLPYVLLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
204	Phosphorylation	VIDHSVNSVINLTDD EEECCCCCEEECCCC	23.40	18327897
256	Phosphorylation	APLPIPSTPSSRQRK CCCCCCCCCCHHHHH	23.10	21082442
258	Phosphorylation	LPIPSTPSSRQRKLK CCCCCCCCHHHHHHH	37.94	19060867
259	Phosphorylation	PIPSTPSSRQRKLKK CCCCCCCHHHHHHHH	33.37	21082442
419	Phosphorylation	TRHEYLESDSPSQIP CCCHHHHCCCHHHCC	40.57	19429919
421	Phosphorylation	HEYLESDSPSQIPKR CHHHHCCCHHHCCCC	35.41	19429919
423	Phosphorylation	YLESDSPSQIPKRRG HHHCCCHHHCCCCCC	44.70	19429919
436	Acetylation	RGRKKGSKGVDALIA CCCCCCCCCHHHHHH	72.17	21791702
541	Phosphorylation	KIDDLGNTDSDTVTS CCHHCCCCCCCCCCC	34.77	22817900
551	Phosphorylation	DTVTSDPSHDSNKSQ CCCCCCCCCCCCCCH	44.94	18327897
1077	Phosphorylation	NLHRNLYSIDSENGM HHHHHCCEECCCCCC	24.08	19429919
1080	Phosphorylation	RNLYSIDSENGMKND HHCCEECCCCCCCCC	31.15	19429919
1126	Phosphorylation	LTIKKTPSKINSPAN EEEECCCCCCCCCCC	51.94	22817900
1177	Phosphorylation	IPQKKDLSKTDRIVH CCCCCCCCHHHHHHH	43.58	22817900
1179	Phosphorylation	QKKDLSKTDRIVHQS CCCCCCHHHHHHHHH	27.43	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MED26_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MED26_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MED26_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CNN_DROME	cnn	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MED26_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204; SER-258; SER-421;THR-541; SER-551; SER-1177 AND THR-1179, AND MASS SPECTROMETRY.	18327897 [Abstract]