KMT5A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KMT5A_DROME
• UniProt AC: Q9VFK6
• Protein Name: Histone-lysine N-methyltransferase PR-Set7 {ECO:0000303|PubMed:12086618}
• Gene Name: PR-Set7 {ECO:0000303|PubMed:12086618, ECO:0000312|FlyBase:FBgn0011474}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 691
• Subcellular Localization: Nucleus. Chromosome. Specifically localizes to mitotic chromosomes. Associates to chromatin-dense and transcriptionally silent euchromatic regions.
• Protein Description: Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis..
• Protein Sequence: MIMVRRRQRPAKEAASSSSGGASSGSGIPVDQALPLNVAGNLLEDQYFASPKRKDCRLMKVTQNGQLPEATMMAHNKDNKAGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEEQLNLGNQELKLDDEELNGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLMDEELQQVVEELLFDGSSRASSNSPFYQHDMDVMQEIQQTPEIPHIKKVTEPLEGLGSLADFQTHRSALRDSHSSTHSSSTDNIFLQEPVLTLDIDRTPTKASSIKINRSFELAGAVFSSPPSVLNACLNGRFNQIVSLNGQKEALDLPHFDLDQHDSSSCDSGVACGLTANTESPAGQPRRRKPATPHRILCPSPIKTALKVTGGICKVGSADPLSPRKSPRKLPTTTAAVAACKSRRRLNQPKPQAPYQPQLQKPPSQQQQQQQDDIVVVLDDDDDEGDDEDDVRALIKAAEERENQNKAPATANSNKAGMKTMLKPAPVKSKTKSKGPTKGQPPLPLAATNGNREMTDFFPVRRSVRKTKTAVKEEWMRGLEQAVLEERCDGLQVRHFMGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDYGDRSKESLLHHPWLAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	LEDQYFASPKRKDCR HHCCCCCCCCCCCCE		30478224
192	Phosphorylation	FDGSSRASSNSPFYQ CCCCCCCCCCCCCHH		22817900
193	Phosphorylation	DGSSRASSNSPFYQH CCCCCCCCCCCCHHH		22817900
195	Phosphorylation	SSRASSNSPFYQHDM CCCCCCCCCCHHHCH		18327897
198	Phosphorylation	ASSNSPFYQHDMDVM CCCCCCCHHHCHHHH		22817900
249	Phosphorylation	DSHSSTHSSSTDNIF CCCCCCCCCCCCCEE		19429919
250	Phosphorylation	SHSSTHSSSTDNIFL CCCCCCCCCCCCEEE		19429919
251	Phosphorylation	HSSTHSSSTDNIFLQ CCCCCCCCCCCEEEC		19429919
252	Phosphorylation	SSTHSSSTDNIFLQE CCCCCCCCCCEEECC		19429919
281	Phosphorylation	SSIKINRSFELAGAV HHCEECCEEEECCEE		22817900
290	Phosphorylation	ELAGAVFSSPPSVLN EECCEEECCCHHHHH		22817900
341	Phosphorylation	SGVACGLTANTESPA CCCCCCCCCCCCCCC		22817900
344	Phosphorylation	ACGLTANTESPAGQP CCCCCCCCCCCCCCC		22817900
346	Phosphorylation	GLTANTESPAGQPRR CCCCCCCCCCCCCCC		22817900
366	Phosphorylation	PHRILCPSPIKTALK CCEEECCCCCCHHHH		25749252
383	Phosphorylation	GGICKVGSADPLSPR CCEECCCCCCCCCCC		22817900
388	Phosphorylation	VGSADPLSPRKSPRK CCCCCCCCCCCCCCC		25749252
392	Phosphorylation	DPLSPRKSPRKLPTT CCCCCCCCCCCCCCH		25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KMT5A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KMT5A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KMT5A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATR_DROME	mei-41	genetic	17227890
PCNA_DROME	PCNA	physical	24806961
PC_DROME	Pc	physical	27002220
DPOLA_DROME	DNApol-alpha180	physical	24806961
BRC1_DROME	br	physical	27002220
BRC4_DROME	br	physical	27002220

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.