| UniProt ID | DPOA2_DROME | |
|---|---|---|
| UniProt AC | Q9VB62 | |
| Protein Name | DNA polymerase alpha subunit B | |
| Gene Name | DNApol-alpha73 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 609 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.. | |
| Protein Sequence | MEEELKQQFDEMGVEPADAVLGRCAELAITYNIHDATEFVEQWMAFSLSHLQGEDPAIENLGDFERKVLQLRKDKAGYKATGQKAKSYGSPSVQDTSSLATYGVMEDDPMLDDYVSESAVDSSALHTPKAKKQSDRTANLKGAALFSPASYTPQSAKRKAGLETPSNSVAGKPGDIVDTFGHPKLLAGSSWQSQMEHTVPVTQKLLHNDAPLTIANLGYMNDLLTDRCHNLRVRFNQTGPALVDKKLGQAGAAECIWYPQDRQVLQSAGGLHAVGMIHSEDDGPLDAHSAFMAVLDDDVEDEMDPTLTLNFSRVKSASIFPGQVVLAKGFIPRGKTFMVEEIHTERKLTPATPLQIDRELQFVVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHKMVGELAETFDTFFEKMIGGIMESIGSHTAVLVVTSQKDAMALSVYPTPPPALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLLSHEFAVNAGERMHRAINHLFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQLPNVLILPSDQRHFIRLVNDCLVINPGRVADKKGGTFARFLVAPSVPGKAANMFNSVACQVQRI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 122 | Phosphorylation | VSESAVDSSALHTPK CCHHHCCHHHCCCCC | 15.77 | 18327897 | |
| 147 | Phosphorylation | LKGAALFSPASYTPQ CCCEECCCCCCCCCH | 22.02 | 28490779 | |
| 150 | Phosphorylation | AALFSPASYTPQSAK EECCCCCCCCCHHHH | 32.68 | 28490779 | |
| 151 | Phosphorylation | ALFSPASYTPQSAKR ECCCCCCCCCHHHHH | 25.25 | 28490779 | |
| 152 | Phosphorylation | LFSPASYTPQSAKRK CCCCCCCCCHHHHHH | 16.62 | 21082442 | |
| 155 | Phosphorylation | PASYTPQSAKRKAGL CCCCCCHHHHHHCCC | 36.64 | 28490779 | |
| 164 | Phosphorylation | KRKAGLETPSNSVAG HHHCCCCCCCCCCCC | 36.74 | 19429919 | |
| 166 | Phosphorylation | KAGLETPSNSVAGKP HCCCCCCCCCCCCCC | 49.51 | 19429919 | |
| 168 | Phosphorylation | GLETPSNSVAGKPGD CCCCCCCCCCCCCCC | 20.06 | 19429919 | |
| 199 | Phosphorylation | QSQMEHTVPVTQKLL HHHHCCCCCCHHHHH | 3.76 | 18327897 | |
| 208 | Phosphorylation | VTQKLLHNDAPLTIA CHHHHHCCCCCEEEE | 47.29 | 18327897 | |
| 210 | Phosphorylation | QKLLHNDAPLTIANL HHHHCCCCCEEEEEC | 13.30 | 18327897 | |
| 212 | Phosphorylation | LLHNDAPLTIANLGY HHCCCCCEEEEECHH | 6.08 | 18327897 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPOA2_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPOA2_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPOA2_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DPOLA_DROME | DNApol-alpha180 | physical | 14605208 | |
| PRI1_DROME | DNApol-alpha50 | physical | 6403945 | |
| DPOLA_DROME | DNApol-alpha180 | physical | 6403945 | |
| PRI2_DROME | DNApol-alpha60 | physical | 6403945 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155; THR-164; SER-166AND SER-168, AND MASS SPECTROMETRY. | |
