DIF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIF_DROME
• UniProt AC: P98149
• Protein Name: Dorsal-related immunity factor Dif
• Gene Name: Dif {ECO:0000312|FlyBase:FBgn0011274}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 667
• Subcellular Localization: Cytoplasm . Nucleus . Accumulates in the nucleus upon bacterial infection of injury.
• Protein Description: Mediates an immune response in larvae. [PubMed: 8242747 DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1]
• Protein Sequence: MFEEAFGDIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYELRLCYQAFITVGNSKVPLDPIVSSPIYGKSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPELLTKHNRRVAQKTVESLKRSLMSTNLHPSKQVKTSSQYTIFSKPQIATTTPQTQVSPGMPLMFPGGSPNFVQDIKMENGFMDVDSQSSQCPSVERNFASPRSNCSTVDSIPPMQMGQNQTHLYLPDATNFTFNGNFASPSSNCSTVDSIPPFQIGQRNNHMYLPENSNFPVNGCSPTHFSGGSMTPINNNNNVLINNNNNDFLSQKMSAISIPPQGNFGIKQVYQQTQQFLPQLQPESIPYLAQSHPEQSQYQQQQQPQEQQPPADEPTQSFSDLISSSIGMAPIDTSELIQDIEAELNSLGIQPFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
343	Phosphorylation	ELKLVRPSDGATSAP EEEEECCCCCCCCCC	37.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
343	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DORS_DROME	dl	genetic	17060622
MED21_DROME	MED21	physical	12556495
CACT_DROME	cact	physical	22654665
CACT_DROME	cact	physical	12653959
CDK8_DROME	Cdk8	physical	12556495
MED31_DROME	MED31	physical	12556495
MED17_DROME	MED17	physical	12556495

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.