dbPTM

PGPLC_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PGPLC_DROME
UniProt AC	Q9GNK5
Protein Name	Peptidoglycan-recognition protein LC
Gene Name	PGRP-LC
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	520
Subcellular Localization	Membrane Single-pass type II membrane protein .
Protein Description	Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. [PubMed: 11872802]
Protein Sequence	MPFSNETEMSQCSNAKRRVNDPLTGPKNCSTSSTDSGVILNDNVAAFRPEKETKDRGTGEGQFQSKSEEKTESKRISVEHTVNITTENVGKTSSPAVSIRSTTISVVSIDDNAIDSSSIDSDSEAEAEDYTVQKLGHQVTYPPNSSHLRDLNQGLTVISRHVAPGEAAVPPPNPLEAGIVAKQILNGNLAVATPTSPAGGATQGIGSIALTNSTDVTFGDKHFYEGPVTIQQFLIDNRDKWKPGEGPAGGQDNPAFNGGPSTNGSAPGSKHEDPAQTPPICPFLPNTVGRKAVTVTVVFVTLTFLLGIVLATTTNLFGKTLNQSKIRDDDDYRQNIPINSTIDLDNIGGGLILRFVERQQWLAQPPQKEIPDLELPVGLVIALPTNSENCSTQAICVLRVRLLQTYDIESSQKCDIAYNFLIGGDGNVYVGRGWNKMGAHMNNINYDSQSLSFAYIGSFKTIQPSAKQLSVTRLLLERGVKLGKIAPSYRFTASSKLMPSVTDFKADALYASFANWTHWS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	KTESKRISVEHTVNI CCCCCCEEEEEEEEE	26.03	19429919
94	Phosphorylation	ENVGKTSSPAVSIRS CCCCCCCCCCEEEEE	23.31	19429919
98	Phosphorylation	KTSSPAVSIRSTTIS CCCCCCEEEEECEEE	17.87	19429919
224	Phosphorylation	TFGDKHFYEGPVTIQ EECCCCEEECCEEEE	21.50	19429919
389	N-linked_Glycosylation	ALPTNSENCSTQAIC ECCCCCCCCCHHHEE	25.51	16556841
461	Phosphorylation	AYIGSFKTIQPSAKQ EEECCCCCCCCCHHH	23.88	22817900
515	N-linked_Glycosylation	ALYASFANWTHWS-- HHHHHHCCCCCCC--	42.01	16556841

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PGPLC_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PGPLC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PGPLC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JUPIT_DROME	Jupiter	physical	23749869
ATPA_DROME	blw	physical	23749869
SODC_DROME	Sod	physical	23749869
HCF_DROME	Hcf	physical	23749869
RS16_DROME	RpS16	physical	23749869
ATC1_DROME	Ca-P60A	physical	23749869
HCD2_DROME	scu	physical	23749869
Y3800_DROME	CG3800	physical	23749869
HSP7D_DROME	Hsc70-4	physical	23749869
RS3_DROME	RpS3	physical	23749869
EF2_DROME	EF2	physical	23749869
RL22_DROME	RpL22	physical	23749869
TBA2_DROME	alphaTub85E	physical	23749869
TBA3_DROME	alphaTub84D	physical	23749869
IF2A_DROME	eIF-2alpha	physical	23749869
CADF_DROME	tsr	physical	23749869
RS28_DROME	RpS28b	physical	23749869
CH60_DROME	Hsp60	physical	23749869
RS20_DROME	RpS20	physical	23749869
STIM_DROME	Stim	physical	23749869
TBA1_DROME	alphaTub84B	physical	23749869
TCPG_DROME	Cctgamma	physical	23749869
CH60C_DROME	Hsp60C	physical	23749869
TAF6_DROME	Taf6	physical	23749869
CATL_DROME	Cp1	physical	23749869
CATA_DROME	Cat	physical	23749869
CUP_DROME	cup	physical	23749869
HSP7E_DROME	Hsc70-5	physical	23749869
LIG_DROME	lig	physical	23749869
EF1A2_DROME	Ef1alpha100E	physical	23749869
EF1A1_DROME	Ef1alpha48D	physical	23749869
ZASP_DROME	Zasp52	physical	23749869
ADT_DROME	sesB	physical	23749869
RS21_DROME	RpS21	physical	23749869
RL7A_DROME	RpL7A	physical	23749869
RS17_DROME	RpS17	physical	23749869
MSL3_DROME	msl-3	physical	23749869
GALE_DROME	Gale	physical	23749869
PRDX1_DROME	Jafrac1	physical	23749869
NCD_DROME	ncd	physical	23749869
PGPLC_DROME	PGRP-LC	physical	23749869
RS10B_DROME	RpS10b	physical	23749869
GBLP_DROME	Rack1	physical	23749869
NH2L1_DROME	hoip	physical	23749869
PGPSD_DROME	PGRP-SD	physical	27851910
PGPLC_DROME	PGRP-LC	physical	15657141

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PGPLC_DROME

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Structure of tracheal cytotoxin in complex with a heterodimericpattern-recognition receptor."; Chang C.-I., Chelliah Y., Borek D., Mengin-Lecreulx D.,Deisenhofer J.; Science 311:1761-1764(2006). Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 355-520 IN COMPLEX WITHPEPTIDOGLYCAN FRAGMENT, DISULFIDE BOND, AND GLYCOSYLATION AT ASN-389AND ASN-515.	16556841 [Abstract]