NETB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NETB_DROME
• UniProt AC: Q24568
• Protein Name: Netrin-B
• Gene Name: NetB
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 793
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Cytoplasm, perinuclear region . Expressed in the perinuclear region of the oldest most anterior lamina neurons at 24 hours after puparium formation.
• Protein Description: Netrins control guidance of CNS commissural axons and peripheral motor axons. [PubMed: 8780645]
• Protein Sequence: MVRATGTRMGLLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRRARKCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	N-linked_Glycosylation	TDLNNPSNVTCWRSG CCCCCCCCCEEEECC	34.08	-
125	N-linked_Glycosylation	PDSAPPDNVTLTLSL CCCCCCCCEEEEEEC	34.15	-
298	N-linked_Glycosylation	YDYNLQDNDSADAGY CCCCCCCCCCCCCCC	31.98	-
686	Phosphorylation	DRASQDISTEKFSIE CCCCCCCCCCCEEHH	38.51	27794539
746	N-linked_Glycosylation	QCPKIKLNKSYLILG CCCCCCCCCCEEEEE	26.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NETB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NETB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NETB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UNC5_DROME	unc-5	genetic	11719202

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.