NUMB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUMB_DROME
• UniProt AC: P16554
• Protein Name: Protein numb
• Gene Name: numb
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 556
• Subcellular Localization: Nucleus . Cytoplasm, cell cortex . In larval brain, shows asymmetric localization and asymmetrically sized divisions in type II secondary neuroblasts.
• Protein Description: Required in determination of cell fate during sensory organ formation in embryos. [PubMed: 2752427 Restricts developmental potential and promote maturation of intermediary neuronal progenitor (INP) cells probably acting as an antagonist of Notch signaling]
• Protein Sequence: MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
335	Phosphorylation	PMQTPLRSVSPIAEV CCCCCCCCCCCCEEC	34.33	19429919
337	Phosphorylation	QTPLRSVSPIAEVSP CCCCCCCCCCEECCH	16.31	19429919
397	Phosphorylation	LNFNNNRSINQNIIA CCCCCCCCCCHHHHH	28.19	22817900
430	Phosphorylation	TPRVASTTPTYQTLH CCCCCCCCCCCHHHC	15.90	22817900
537	Phosphorylation	RSPLARHSTNPFISP CCCCHHCCCCCCCCC	25.07	18327897
543	Phosphorylation	HSTNPFISPPKAPAQ CCCCCCCCCCCCCCC	35.21	2752427

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUMB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUMB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUMB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TULP_DROME	ktub	physical	14605208
APKC_DROME	aPKC	physical	17203073
NOTCH_DROME	N	genetic	8755476
NOTCH_DROME	N	genetic	21558368
SUH_DROME	Su(H)	genetic	9409662
FBXW7_DROME	ago	genetic	22140513
DRONC_DROME	Nc	genetic	21558368
CCNA_DROME	CycA	genetic	10331986
BRM_DROME	brm	genetic	24550111
HLES_DROME	H	genetic	9409662
NOTCH_DROME	N	physical	8755476
AP2A_DROME	AP-2alpha	physical	12194853
AP2A_DROME	AP-2alpha	physical	16139215
AP2A_DROME	AP-2alpha	physical	18854163
AP2A_DROME	AP-2alpha	physical	23523246
DRONC_DROME	Nc	physical	21558368
APKC_DROME	aPKC	physical	18854163

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-430; SER-537 ANDSER-543, AND MASS SPECTROMETRY.
PubMed: 18327897