HOOK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOOK_DROME
• UniProt AC: Q24185
• Protein Name: Protein hook
• Gene Name: hook {ECO:0000312|FlyBase:FBgn0001202}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 679
• Subcellular Localization: Cytoplasm, cytoskeleton. Endosome . Cell junction, synapse . Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.
• Protein Description: Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity..
• Protein Sequence: MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRALQELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRAKDSLLKERDNLREAVDELKCGQLSSNTALTGTTVSRELQPSATVEKLQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVLEKSADLVEEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	EATRQASTPEGGVAS HHHHCCCCCCCCHHH	28.51	21082442
170	Phosphorylation	PEGGVASSLSRGSRT CCCCHHHHCCCCCCC	22.19	21082442
510	Phosphorylation	TANERILSLSHASQS HHHHHHHHHHHCCCC	26.00	19429919
512	Phosphorylation	NERILSLSHASQSDD HHHHHHHHHCCCCCC	17.40	19429919
515	Phosphorylation	ILSLSHASQSDDPIL HHHHHHCCCCCCCCC	25.45	19429919
517	Phosphorylation	SLSHASQSDDPILKE HHHHCCCCCCCCCCH	41.30	19429919
610	Phosphorylation	DASVLEKSADLVEEE CHHHHHHHHCCCCCC	20.03	27794539
672	Phosphorylation	RQSAPRKSLSAMKSK HHHCCHHHHHHHHCC	28.92	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOOK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOOK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOOK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLIP1_DROME	Slip1	physical	14605208
INAD_DROME	inaD	physical	14605208
NDE1_DROME	nudE	physical	14605208
AKTP1_DROME	cbx	physical	22036573
VPS18_DROME	dor	genetic	11018772

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.