SH3G3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3G3_DROME
• UniProt AC: Q8T390
• Protein Name: Endophilin-A
• Gene Name: EndoA {ECO:0000312|FlyBase:FBgn0038659}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 369
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Associated with internal membranes. Expressed presynaptically at NMJs.
• Protein Description: Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis..
• Protein Sequence: MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRGAEDKFGESLQLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLPNGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	VKGISKLSGQAKSNT HHHHHHHCCCCCCCC	32.37	22817900
276	Phosphorylation	GGLNEDGTPSHISSS CCCCCCCCCCCCCCC	33.66	19429919
278	Phosphorylation	LNEDGTPSHISSSAS CCCCCCCCCCCCCCC	33.04	19429919
281	Phosphorylation	DGTPSHISSSASPLP CCCCCCCCCCCCCCC	16.90	19429919
282	Phosphorylation	GTPSHISSSASPLPS CCCCCCCCCCCCCCC	29.35	19429919
283	Phosphorylation	TPSHISSSASPLPSP CCCCCCCCCCCCCCC	26.44	19429919
285	Phosphorylation	SHISSSASPLPSPMR CCCCCCCCCCCCCCC	28.99	19429919
289	Phosphorylation	SSASPLPSPMRSPAK CCCCCCCCCCCCCCH	38.72	19429919
293	Phosphorylation	PLPSPMRSPAKSMAV CCCCCCCCCCHHCCC	23.98	19429919
297	Phosphorylation	PMRSPAKSMAVTPQR CCCCCCHHCCCCCHH	17.68	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH3G3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3G3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3G3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCHS_DROME	Hdc	physical	14605208
ARMET_DROME	Manf	physical	14605208
DORS_DROME	dl	physical	14605208
HSP7E_DROME	Hsc70-5	physical	14605208
DYN_DROME	shi	physical	24977345

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-289 ANDSER-293, AND MASS SPECTROMETRY.
PubMed: 18327897