dbPTM

DCHS_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCHS_DROME
UniProt AC	Q05733
Protein Name	Histidine decarboxylase
Gene Name	Hdc
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	847
Subcellular Localization
Protein Description	Required in photoreceptor transmitter synthesis..
Protein Sequence	MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVHRTFNVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDDIVKDWMEIRQVASTVLEEMNITISNRVYLKETKEKNEAFGSSLLLSNSPLSPKVVNGSFAAIFDADEFLAKTYAGVRIAHQESPSMRRRVRGILMSGKQFSLDSHMDVVVQTTLDAGNGATRTSTTNSYGHTTSAAQANSERQASIQEDNEESPEETELLSLCRTSNVPSPEHAHSLSTPSRSCSSSSHSLIHSLTQSSPRSSPVNQFRPITLCAVPSQSQLSMPLAMPLPNRNVTVSVDSLLNPVTTCNVYHGKRFLEPLENLAQTSASFSSSIFRLPTPIATPTRESPEDPDWPAKTFSQLLLERYSSQSQSLGNNSSTESSSLSGGATPTPTPMSSLDELVTPLLLSFASPSQPMLSAHGIGEGQREQGSDSDATVCSTTSSMESL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
304	N6-(pyridoxal phosphate)lysine	SIAFNPSKWLMVHFD HEEECHHCEEEEEEE	45.67	-
304	Other	SIAFNPSKWLMVHFD HEEECHHCEEEEEEE	45.67	-
623	Phosphorylation	ELLSLCRTSNVPSPE HHHHHHHCCCCCCHH	24.53	22817900
624	Phosphorylation	LLSLCRTSNVPSPEH HHHHHHCCCCCCHHH	19.24	22817900
628	Phosphorylation	CRTSNVPSPEHAHSL HHCCCCCCHHHHCCC	38.34	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCHS_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCHS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCHS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DCHS_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCHS_DROME

Related Literatures of Post-Translational Modification