ARMET_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMET_DROME
• UniProt AC: Q9XZ63
• Protein Name: Mesencephalic astrocyte-derived neurotrophic factor homolog
• Gene Name: Manf
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 173
• Subcellular Localization: Secreted .
• Protein Description: Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels..
• Protein Sequence: MKTWYMVVVIGFLATLAQTSLALKEEDCEVCVKTVRRFADSLDDSTKKDYKQIETAFKKFCKAQKNKEHRFCYYLGGLEESATGILNELSKPLSWSMPAEKICEKLKKKDAQICDLRYEKQIDLNSVDLKKLKVRDLKKILNDWDESCDGCLEKGDFIKRIEELKPKYSRSEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Acetylation	DSTKKDYKQIETAFK CCCHHHHHHHHHHHH	55.74	21791702
83	Phosphorylation	GGLEESATGILNELS CCCHHHHHHHHHHHC	33.75	22668510
96	Phosphorylation	LSKPLSWSMPAEKIC HCCCCCCCCCHHHHH	16.12	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMET_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMET_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMET_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERD2_DROME	KdelR	genetic	27365452

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.