NCASE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCASE_DROME
• UniProt AC: Q9VA70
• Protein Name: Neutral ceramidase
• Gene Name: CDase
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 704
• Subcellular Localization: Secreted .
• Protein Description: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition..
• Protein Sequence: MANSKMAFLAFLAVSFLCGLVSATYKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKGNRVAFVSADAGMMGYGLKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQTFEVMAQGLYLCIKRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLGAFNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKGKFVGAFCSSNLGDVSPNIMGPKCSISGNECDLLTSRCPTGEGDCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVTGDVRFIHQFVDMPNYNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTDNPMWNFVRDFIAAPTQEDIKCHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTTMAGRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMDVFERLTKAMMRNETVDAGPSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKSQPNKEYGINETVKVTYISGNPRNNLFTEKTYFTIERKINEDRWKVAYTDASWETKMVWHRTNTILGFSEMDIYWDISPQTLPGEYRIRHSGEYKYILGGKYPYEGLTHSFTVKED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
230	N-linked_Glycosylation	AVHATSMNNTNRLVT EEEEECCCCCCCEEC	52.52	-
337	Phosphorylation	LGLLNEQSQESTARE HHHHCHHCHHCHHHH	29.72	22668510
340	Phosphorylation	LNEQSQESTAREVTG HCHHCHHCHHHHHHC	21.52	23607784
362	N-linked_Glycosylation	FVDMPNYNGSTYNPL ECCCCCCCCCCCCCH	44.58	-
550	N-linked_Glycosylation	LTKAMMRNETVDAGP HHHHHHCCCCCCCCC	31.24	-
598	N-linked_Glycosylation	PNKEYGINETVKVTY CCCCCCCCCEEEEEE	34.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCASE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCASE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCASE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACASE_DROME	bwa	genetic	21148295

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.