| UniProt ID | GCH1_DROME | |
|---|---|---|
| UniProt AC | P48596 | |
| Protein Name | GTP cyclohydrolase 1 | |
| Gene Name | Pu | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 324 | |
| Subcellular Localization | ||
| Protein Description | Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation.. | |
| Protein Sequence | MSFTRQLSEMSASELNDAIDDTNFPQAHILSRGRNNSVCSTSSTSGTSSLADRQQNQAEEATAIAGTPVEEVAPAPALVPLAGNQRPRLILKTNGSSPDSDGTQPKTPLTPRTSTTPGHEKCTFHHDLELDHKPPTREALLPDMARSYRLLLGGLGENPDRQGLIKTPERAAKAMLYFTKGYDQSLEDVLNGAVFDEDHDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPCNKILGLSKLARIVEIFSRRLQVQERLTKQIAVAVTQAVQPAGVAVVVEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVNSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 63 (in isoform 2) | Phosphorylation | - | 9.18 | 27794539 | |
| 66 (in isoform 2) | Phosphorylation | - | 25.16 | 27794539 | |
| 93 | Phosphorylation | RPRLILKTNGSSPDS CCEEEEEECCCCCCC | 41.17 | 19429919 | |
| 96 | Phosphorylation | LILKTNGSSPDSDGT EEEEECCCCCCCCCC | 40.54 | 19429919 | |
| 97 | Phosphorylation | ILKTNGSSPDSDGTQ EEEECCCCCCCCCCC | 33.84 | 19429919 | |
| 97 (in isoform 3) | Phosphorylation | - | 33.84 | 27794539 | |
| 103 | Phosphorylation | SSPDSDGTQPKTPLT CCCCCCCCCCCCCCC | 46.84 | 19429919 | |
| 107 | Phosphorylation | SDGTQPKTPLTPRTS CCCCCCCCCCCCCCC | 30.16 | 19429919 | |
| 110 | Phosphorylation | TQPKTPLTPRTSTTP CCCCCCCCCCCCCCC | 16.36 | 19429919 | |
| 116 | Phosphorylation | LTPRTSTTPGHEKCT CCCCCCCCCCCCCCE | 27.34 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCH1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCH1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCH1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FGFR2_DROME | btl | genetic | 17585895 | |
| NDKA_DROME | awd | genetic | 17585895 | |
| DYN_DROME | shi | genetic | 17585895 | |
| CSUP_DROME | Catsup | genetic | 17585895 | |
| CSUP_DROME | Catsup | physical | 21985068 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
