| UniProt ID | RU17_DROME | |
|---|---|---|
| UniProt AC | P17133 | |
| Protein Name | U1 small nuclear ribonucleoprotein 70 kDa | |
| Gene Name | snRNP-U1-70K | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 448 | |
| Subcellular Localization | Nucleus. Nucleus speckle. Nucleus, nucleoplasm. | |
| Protein Description | Mediates the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA. [PubMed: 15611175 Required during oogenesis for nurse cell chromatin dispersal] | |
| Protein Sequence | MTQYLPPNLLALFAAREPIPFMPPVDKLPHEKKSRGYLGVAKFMADFEDPKDTPLPKTVETRQERLERRRREKAEQVAYKLEREIALWDPTEIKNATEDPFRTLFIARINYDTSESKLRREFEFYGPIKKIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRRLGGGLGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSRSRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKKKRSKSRERESSRERRERKRERRDRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYPTFDYQNATIKREIDDEDEEKYRPPPAHHNMFSVPPPPILGRGNASTNPNPDNGQQSSGDPSWWRQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 240 | Phosphorylation | GPGRGGGSNGLDARP CCCCCCCCCCCCCCC | 30.88 | 22817900 | |
| 295 | Phosphorylation | RRKRRAGSRERYDEF HHHHHHCHHHHHHHH | 29.95 | 22668510 | |
| 352 | Phosphorylation | RRDRERGTGSGGDVK HHHHHCCCCCCCCCC | 34.10 | 19429919 | |
| 354 | Phosphorylation | DRERGTGSGGDVKER HHHCCCCCCCCCCCC | 39.17 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RU17_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RU17_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RU17_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| U430_DROME | CG31712 | physical | 22036573 | |
| PUF68_DROME | pUf68 | physical | 22036573 | |
| NKAP_DROME | CG6066 | physical | 22036573 | |
| RU2A_DROME | U2A | physical | 22036573 | |
| PREP_DROME | CG3107 | physical | 22036573 | |
| SMD2_DROME | SmD2 | physical | 22036573 | |
| RU1C_DROME | snRNP-U1-C | physical | 22036573 | |
| IF4E_DROME | eIF-4E | physical | 21829374 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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