dbPTM

RU2A_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RU2A_DROME
UniProt AC	Q9V4Q8
Protein Name	Probable U2 small nuclear ribonucleoprotein A'
Gene Name	U2A
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	265
Subcellular Localization	Nucleus .
Protein Description	Involved in pre-mRNA splicing as component of the spliceosome (By similarity). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (By similarity). In the germ line, has a role in oogenesis, by regulating spermatogenesis and nurse cell nuclei chromatin decondensation and dispersal, probably by regulating the splicing of proteins necessary for germline differentiation such as the meiotic protein mei-P26. [PubMed: 27035939]
Protein Sequence	MVKLTPELINQSMQYINPCRERELDLRGYKIPQIENLGATLDQFDTIDLSDNDLRKLDNLPHLPRLKCLLLNNNRILRISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKLETICLLINPVSTKPNYREYMAYKFPQLRLLDFRKIKQKDRQAAQEFFRTKQGKDVLKEISRKSKMSAAAAIAAEAGNGKGRGSEGGRLANPQDMQRIREAIKRASSLAEVERLSQILQSGQLPDKFQHEMEAVAQNGAGHNGSGAVAMEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
220	Phosphorylation	REAIKRASSLAEVER HHHHHHHHHHHHHHH	29.89	19429919
221	Phosphorylation	EAIKRASSLAEVERL HHHHHHHHHHHHHHH	30.52	19429919
229	Phosphorylation	LAEVERLSQILQSGQ HHHHHHHHHHHHHCC	22.77	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RU2A_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RU2A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RU2A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMN_DROME	Smn	physical	22036573
GEMI2_DROME	Gem2	physical	22036573
SNRPA_DROME	snf	physical	11557816
SNRPA_DROME	snf	physical	20221253

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RU2A_DROME

Related Literatures of Post-Translational Modification