VIT3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VIT3_DROME
• UniProt AC: P06607
• Protein Name: Vitellogenin-3
• Gene Name: Yp3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 420
• Subcellular Localization: Secreted.
• Protein Description: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis..
• Protein Sequence: MMSLRICLLATCLLVAAHASKDASNDRLKPTKWLTATELENVPSLNDITWERLENQPLEQGAKVIEKIYHVGQIKHDLTPSFVPSPSNVPVWIIKSNGQKVECKLNNYVETAKAQPGFGEDEVTIVLTGLPKTSPAQQKAMRRLIQAYVQKYNLQQLQKNAQEQQQQLKSSDYDYTSSEEAADQWKSAKAASGDLIIIDLGSTLTNFKRYAMLDVLNTGAMIGQTLIDLTNKGVPQEIIHLIGQGISAHVAGAAGNKYTAQTGHKLRRITGLDPAKVLSKRPQILGGLSRGDADFVDAIHTSTFAMGTPIRCGDVDFYPNGPSTGVPGSENVIEAVARATRYFAESVRPGSERNFPAVPANSLKQYKEQDGFGKRAYMGLQIDYDLRGDYILEVNAKSPFGQRSPAHKQAAYHGMHHAQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	AHASKDASNDRLKPT HHHCCCCCCCCCCCC	49.77	27794539
37	Phosphorylation	PTKWLTATELENVPS CCCEEEHHHHCCCCC	35.55	18327897
176	Phosphorylation	KSSDYDYTSSEEAAD HHCCCCCCCCHHHHH	23.91	30478224
177	Phosphorylation	SSDYDYTSSEEAADQ HCCCCCCCCHHHHHH	29.53	22817900
178	Phosphorylation	SDYDYTSSEEAADQW CCCCCCCCHHHHHHH	31.49	22817900
384	Sulfation	YMGLQIDYDLRGDYI CCEEEEEEECCCCEE	20.64	-
384	Sulfation	YMGLQIDYDLRGDYI CCEEEEEEECCCCEE	20.64	-
390	Sulfation	DYDLRGDYILEVNAK EEECCCCEEEEEECC	15.38	-
390	Sulfation	DYDLRGDYILEVNAK EEECCCCEEEEEECC	15.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VIT3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VIT3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VIT3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FTZF1_DROME	ftz-f1	physical	14605208
MED9_DROME	MED9	physical	14605208
ARI2_DROME	ari-2	physical	14605208
APLP_DROME	Rfabg	physical	22036573
VIT2_DROME	Yp2	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-37; SER-177 AND SER-178,AND MASS SPECTROMETRY.
PubMed: 18327897