VIT1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VIT1_DROME
• UniProt AC: P02843
• Protein Name: Vitellogenin-1
• Gene Name: Yp1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 439
• Subcellular Localization: Secreted.
• Protein Description: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis..
• Protein Sequence: MNPMRVLSLLACLAVAALAKPNGRMDNSVNQALKPSQWLSGSQLEAIPALDDFTIERLENMNLERGAELLQQVYHLSQIHHNVEPNYVPSGIQVYVPKPNGDKTVAPLNEMIQRLKQKQNFGEDEVTIIVTGLPQTSETVKKATRKLVQAYMQRYNLQQQRQHGKNGNQDYQDQSNEQRKNQRTSSEEDYSEEVKNAKTQSGDIIVIDLGSKLNTYERYAMLDIEKTGAKIGKWIVQMVNELDMPFDTIHLIGQNVGAHVAGAAAQEFTRLTGHKLRRVTGLDPSKIVAKSKNTLTGLARGDAEFVDAIHTSVYGMGTPIRSGDVDFYPNGPAAGVPGASNVVEAAMRATRYFAESVRPGNERSFPAVPANSLQQYKQNDGFGKRAYMGIDTAHDLEGDYILQVNPKSPFGRNAPAQKQSSYHGVHQAWNTNQDSKDYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	PNGRMDNSVNQALKP CCCCCCCHHHHCCCH	20.41	30478224
40	Phosphorylation	LKPSQWLSGSQLEAI CCHHHCCCHHHCCCC	33.18	30478224
171	Phosphorylation	GKNGNQDYQDQSNEQ CCCCCHHHHHHHHHH	12.29	28490779
175	Phosphorylation	NQDYQDQSNEQRKNQ CHHHHHHHHHHHHHH	51.10	28490779
184	Phosphorylation	EQRKNQRTSSEEDYS HHHHHHCCCCHHHHH	27.17	28490779
185	Phosphorylation	QRKNQRTSSEEDYSE HHHHHCCCCHHHHHH	37.63	28490779
186	Phosphorylation	RKNQRTSSEEDYSEE HHHHCCCCHHHHHHH	44.38	28490779
190	Phosphorylation	RTSSEEDYSEEVKNA CCCCHHHHHHHHHHH	22.66	28490779
191	Phosphorylation	TSSEEDYSEEVKNAK CCCHHHHHHHHHHHC	39.33	28490779
291	Phosphorylation	PSKIVAKSKNTLTGL HHHHEEECCCCCHHH	22.77	22817900
356	Phosphorylation	ATRYFAESVRPGNER HHHHHHHHCCCCCCC	21.72	22817900
431	Phosphorylation	GVHQAWNTNQDSKDY CHHHCCCCCCCCCCC	24.45	30478224
435	Phosphorylation	AWNTNQDSKDYQ--- CCCCCCCCCCCC---	20.05	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VIT1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VIT1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VIT1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRP68_DROME	Srp68	physical	14605208
MNB_DROME	mnb	physical	14605208
VIT3_DROME	Yp3	physical	22036573
VIT2_DROME	Yp2	physical	22036573
APLP_DROME	Rfabg	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-171; SER-175; SER-185;SER-186; TYR-190; SER-191 AND SER-435, AND MASS SPECTROMETRY.
PubMed: 18327897