dbPTM

LTV1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LTV1_DROME
UniProt AC	Q7KN79
Protein Name	Protein LTV1 homolog
Gene Name	CG7686
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	493
Subcellular Localization
Protein Description
Protein Sequence	MVKGKKPYIDRKKAVTFHLVHRSQHDPLVTDENAPQRVLLEAAARQQKPKDPEPPTDPAQRQEELKKFGIHFDDDYDYMQHLKKRENDVVWEFMENPNQARKQKVQDSEKPGPAPKLMLPSSVFASEFEESEGMLNKAAPQTLRLDWDPDVVAALDSDCENEELEDDFVIQAMAEGDSDDEEWDDEDGEEQSDMDFDSDDLNEDENEDELMDRLAPLMRERRFDDEEVKSRFTEYSMSSSVIRRNEQLSLLDDRFEKFYATYDDPELGDLALEDIEGNWHQKHPVVMQCFQEFKKKDKGIEYNKEWDRERIEKYRNVVEGEEDPTEELVEYEVDDPKQKKWDCESILSTYSNIYNHPKVIDEPRRSRRSSASTNPAPIQIDPKTGLPTNVLRGGVDGQLTAKALANLADESPAATGPKSLCAKSVLSTLSVLSIRPKDETHEEKKERKRLLKDYRNERRIEKKANTEAFKEEKKRQTHVKINQRTNQQGASIV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
236	Phosphorylation	KSRFTEYSMSSSVIR HHHHHHHHCCHHHHH	13.12	21082442
345	Phosphorylation	QKKWDCESILSTYSN HCCCCHHHHHHHHHH	34.85	22817900
349	Phosphorylation	DCESILSTYSNIYNH CHHHHHHHHHHHHCC	27.76	22817900
366	Phosphorylation	VIDEPRRSRRSSAST HCCCCCCCCCCCCCC	33.07	21082442
369	Phosphorylation	EPRRSRRSSASTNPA CCCCCCCCCCCCCCC	29.19	19429919
370	Phosphorylation	PRRSRRSSASTNPAP CCCCCCCCCCCCCCC	25.16	19429919
372	Phosphorylation	RSRRSSASTNPAPIQ CCCCCCCCCCCCCCC	30.57	19429919
373	Phosphorylation	SRRSSASTNPAPIQI CCCCCCCCCCCCCCC	44.96	19429919
424	Phosphorylation	PKSLCAKSVLSTLSV CHHHHHHHHHHHHHH	15.12	22817900
427	Phosphorylation	LCAKSVLSTLSVLSI HHHHHHHHHHHHHHC	25.75	22817900
430	Phosphorylation	KSVLSTLSVLSIRPK HHHHHHHHHHHCCCC	22.54	22817900
433	Phosphorylation	LSTLSVLSIRPKDET HHHHHHHHCCCCCCC	17.88	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LTV1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LTV1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LTV1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MYC_DROME	dm	genetic	25858587
RS3_DROME	RpS3	physical	25858587

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LTV1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345; SER-369; SER-370;SER-424 AND SER-427, AND MASS SPECTROMETRY.	18327897 [Abstract]