GAWKY_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAWKY_DROME
• UniProt AC: Q8SY33
• Protein Name: Protein Gawky {ECO:0000312|FlyBase:FBgn0051992}
• Gene Name: gw
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1384
• Subcellular Localization: Cytoplasm, P-body .
• Protein Description: Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development..
• Protein Sequence: MREALFSQDGWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSINNGTDLWESNLRNGGQPAAQQVPKPSWGHTPSSNLGGTWGEDDDGADSSSVWTGGAVSNAGSGAAVGVNQAGVNVGPGGVVSSGGPQWGQGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAGNGWGDPREIRPLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGTSEMWGHHPQMSHNQLQGINKMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNIPTQWGPAQPVSVGVSGPKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIGRSSHLMRGQSQTGGIGIAGVGNSNVPVGANPSNPISSVVGPQARIPSVGGVQHKPDGGAMWVHSGNVGGRNNVAAVTTWGDDTHSVNVGAPSSGSVSSNNWVDDKSNSTLAQNSWSDPAPVGVSWGNKQSKPPSNSASSGWSTAAGVVDGVDLGSEWNTHGGIIGKSQQQQKLAGLNVGMVNVINAEIIKQSKQYRILVENGFKKEDVERALVIANMNIEEAADMLRANSSLSMDGWRRHDESLGSYADHNSSTSSGGFAGRYPVNSGQPSMSFPHNNLMNNMGGTAVTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVGFGQNTSNAAVAGAASVNIAANTNNQPSGQQIRMLGQQIQLAIHSGFISSQILTQPLTQTTLNLLNQLLSNIKHLQAAQQSLTRGGNVNPMAVNVAISKYKQQIQNLQNQINAQQAVYVKQQNMQPTSQQQQPQQQQLPSVHLSNSGNDYLRGHDAINNLQSNFSELNINKPSGYQGASNQQSRLNQWKLPVLDKEINSDSTEFSRAPGATKQNLTANTSNINSLGLQNDSTWSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDDPSITPGSVARSPLSINSTPKDADIFANTGKNSPTDLPPLSLSSSTWSFNPNQNYPSHSWSDNSQQCTATSELWTSPLNKSSSRGPPPGLTANSNKSANSNASTPTTITGGANGWLQPRSGGVQTTNTNWTGGNTTWGSSWLLLKNLTAQIDGPTLRTLCMQHGPLVSFHPYLNQGIALCKYTTREEANKAQMALNNCVLANTTIFAESPSENEVQSIMQHLPQTPSSTSSSGTSGGNVGGVGTSANNANSGSAACLSGNNSGNGNGSASGAGSGNNGNSSCNNSAAGGGSSSNNTITTVANSNLVGSSGSVSNSSGVTANSSTVSVVSCTASGNSINGAGTANSSGSKSSANNLASGQSSASNLTNSTNSTWRQTSQNQALQSQSRPSGREADFDYISLVYSIVDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
314	Phosphorylation	KDMSKQISGWEEPSP CCCCHHCCCCCCCCC	35.05	21082442
320	Phosphorylation	ISGWEEPSPPPQRRS CCCCCCCCCCCCCCC	54.00	19429919
327	Phosphorylation	SPPPQRRSIPNYDDG CCCCCCCCCCCCCCC	44.58	19429919
357	Phosphorylation	HWKDMTDSIGRSSHL CHHHCHHHCCCCHHH	20.13	19429919
369	Phosphorylation	SHLMRGQSQTGGIGI HHHHCCCCCCCCCCC	32.31	21082442
371	Phosphorylation	LMRGQSQTGGIGIAG HHCCCCCCCCCCCCC	42.49	21082442
406	Phosphorylation	GPQARIPSVGGVQHK CCCCCCCCCCCCEEC	30.90	19429919
602	Phosphorylation	GWRRHDESLGSYADH CHHHCCCCCCCCCCC	44.05	21082442
605	Phosphorylation	RHDESLGSYADHNSS HCCCCCCCCCCCCCC	23.57	21082442
852	Phosphorylation	NNLQSNFSELNINKP HHHHHHHHHCCCCCC	45.48	21082442
934	Phosphorylation	GDGWPDPSSDNENKD CCCCCCCCCCCCCCC	58.67	19429919
935	Phosphorylation	DGWPDPSSDNENKDW CCCCCCCCCCCCCCC	50.25	19429919
974	Phosphorylation	WKGSQIKSIEDDPSI CCCCCCEECCCCCCC	32.60	25749252
989	Phosphorylation	TPGSVARSPLSINST CCCCCCCCCCCCCCC	22.06	19429919
992	Phosphorylation	SVARSPLSINSTPKD CCCCCCCCCCCCCCC	24.10	21082442
1074	Phosphorylation	LTANSNKSANSNAST CCCCCCCCCCCCCCC	36.61	19429919
1077	Phosphorylation	NSNKSANSNASTPTT CCCCCCCCCCCCCCE	33.23	19429919
1080	Phosphorylation	KSANSNASTPTTITG CCCCCCCCCCCEECC	38.89	19429919
1081	Phosphorylation	SANSNASTPTTITGG CCCCCCCCCCEECCC	23.42	19429919
1083	Phosphorylation	NSNASTPTTITGGAN CCCCCCCCEECCCCC	30.80	19429919
1084	Phosphorylation	SNASTPTTITGGANG CCCCCCCEECCCCCC	20.11	19429919
1086	Phosphorylation	ASTPTTITGGANGWL CCCCCEECCCCCCCC	27.72	19429919
1354	Phosphorylation	NSTWRQTSQNQALQS CCCCCHHHHHHHHHH	20.85	21082442
1366	Phosphorylation	LQSQSRPSGREADFD HHHCCCCCCCCCCCC	49.74	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GAWKY_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAWKY_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAWKY_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP_DROME	pAbp	physical	19797087
PABP_DROME	pAbp	physical	21063388
CNOT1_HUMAN	CNOT1	physical	21984184
CNOT8_HUMAN	CNOT8	physical	21984184
RGA_DROME	Rga	physical	21981923
PAN3_DROME	CG11486	physical	21981923
RGA_DROME	Rga	physical	23172285
PAN3_DROME	CG11486	physical	23172285
PABP_DROME	pAbp	physical	23172285

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.