RGA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGA_DROME
• UniProt AC: Q94547
• Protein Name: Regulator of gene activity
• Gene Name: Rga
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 585
• Protein Description: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Essential for viability. Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes..
• Protein Sequence: MANLNFQQPPRSIANAALAGRTTGGFGGSSLAGHVTPTSGMFQTDFANSYPGTANYGQAPQQQQQQQQQPQLSPNRNAQLSVGGPAISSGNRNANLFGQRQFVERRAMQGLGSGPMSNMGNFMQTGRGGYGTGGGGGGPLNNFHVFGGGGGSDTSTPALLDPTEFPSLTNARGQNDQTLPQSNPLQPPGSKPYGNFFTSFGMVKQPTSEQSEFTMSNEDFPALPGTQNSDGTTNAVGSVAGTGGSGGASTENHLDGTEKPMNSIVVSGSASGSSGSNVGVVGGNGLGAVGSGIGGLAVGGGGGAGSSGGGGVGGNAASGVVGGSHVGLVGSNSGIGGVNSVPNSNAMMGVGGGLGSGSGSSGSGAGGEHLNDNSSNDKLVKSGVQTSPDGKVTNIPATMVNNQFGMVGLLTFIRAAETDPNLVTLSLGTDLTGLGLNLNSQESLHTTFAGPFVAQPCRAQDVEFNVPPEYLINFAIRDKLTAPVLKKLQEDLLFFLFYTNIGDMMQLMAAAELHSREWRYHVEEKIWITRIPGIDQYEKNGTKERGTFYYFDAQSWKRLSKVFQIDPEKLDKCPNISAFMNGQSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	NFQQPPRSIANAALA CCCCCCHHHHHHHHC	31.65	21082442
73	Phosphorylation	QQQQPQLSPNRNAQL HHHCCCCCCCCCCEE	18.19	30478224
81	Phosphorylation	PNRNAQLSVGGPAIS CCCCCEEEECCCCCC	13.46	21082442
167	Phosphorylation	LDPTEFPSLTNARGQ CCCCCCCCCCCCCCC	53.82	22817900
387	Phosphorylation	VKSGVQTSPDGKVTN HHHCCEECCCCCCCC	12.14	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUP_DROME	cup	physical	21937713
PABP_DROME	pAbp	physical	19797087
Y1505_DROME	CG11505	physical	25242320
NANOS_DROME	nos	physical	21081899

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.