THOC7_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THOC7_DROME
• UniProt AC: Q8IRJ8
• Protein Name: THO complex protein 7
• Gene Name: thoc7
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 288
• Subcellular Localization: Cytoplasm . Nucleus . Nucleus speckle .
• Protein Description: The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress..
• Protein Sequence: MSEQCQLRPHSDTLVRKLVEMNDEEIIKQRLLIDGDGTGEDRRIVVLLKQFLKWASDSLDSNPIMYDRLMAQFAQCKLTALKNVQTLQMIAGERDNYTQLVEHHEESIVLAKAEIESSKKELITAKQIRKNKMEYDLLASLIQDQPDRSETQRHIETIRREIDDLVQKKLKMERKFQKRRNDFTLLMYTIHELEQQLDQDSSSSASSSSSDCDARSEPDLDDNGIMEVSDEDDDLNNSTPTKFDGARGEPKYHSVSTEDSKAMSVEEDTVLELSIDKDEHDVDVAVAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
216	Phosphorylation	SSDCDARSEPDLDDN CCCCCCCCCCCCCCC	56.02	19429919
229	Phosphorylation	DNGIMEVSDEDDDLN CCCEEECCCCCCCCC	23.21	19429919
254	Phosphorylation	RGEPKYHSVSTEDSK CCCCCCCCCCCCCCC	18.05	19429919
256	Phosphorylation	EPKYHSVSTEDSKAM CCCCCCCCCCCCCCC	29.15	18327897
260	Phosphorylation	HSVSTEDSKAMSVEE CCCCCCCCCCCCCCC	18.97	15133499

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THOC7_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THOC7_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THOC7_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCDCX_DROME	CG32809	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-229; SER-256AND SER-260, AND MASS SPECTROMETRY.
PubMed: 18327897