LSG1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSG1_DROME
• UniProt AC: Q9W590
• Protein Name: Large subunit GTPase 1 homolog
• Gene Name: Ns3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 606
• Subcellular Localization: Cytoplasm . Punctate distribution.
• Protein Description: GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control..
• Protein Sequence: MGKKNKGGAPNLGRQLIKDRFGHTQRRKVDNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAFLRTAELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWTKETSAEELVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPLLFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLDSFPEVQQLRRAVEEIKQSLDSVEDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYNRGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQLPGQQQRAMRINKSTSKELDNQFFSDKPTHAHVKGRTNFPNVRLANDGSLVAGNDPAAKPWRHVKKERREKLRKKFSHLDEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	QAEKLNITFVNPKQR EEEECCCEECCHHHH	22.06	21082442
276	Phosphorylation	AVEEIKQSLDSVEDA HHHHHHHHHHHHHHH	29.19	22817900
279	Phosphorylation	EIKQSLDSVEDALNV HHHHHHHHHHHHHHH	32.47	22817900
538	Phosphorylation	RAMRINKSTSKELDN HHHHHCCCCCHHHHH	33.16	21082442
539	Phosphorylation	AMRINKSTSKELDNQ HHHHCCCCCHHHHHC	45.48	21082442
540	Phosphorylation	MRINKSTSKELDNQF HHHCCCCCHHHHHCC	31.09	21082442
601	Phosphorylation	EKLRKKFSHLDEH-- HHHHHHHHCCCCC--	31.83	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSG1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSG1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSG1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276 AND SER-279, ANDMASS SPECTROMETRY.
PubMed: 18327897