MAX_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAX_DROME
• UniProt AC: P91664
• Protein Name: Protein max
• Gene Name: Max
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 161
• Subcellular Localization: Nucleus.
• Protein Description: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor..
• Protein Sequence: MSMSDDDRDIDIESDEDGDSDTGLGSSRHTNTANFTQAEKRAHHNALERRRRDHIKESFTNLREAVPTLKGEKASRAQILKKTTECIQTMRRKISENQKDIEEIKRQNNIIAKQIQALESSNGDQFSEFLSDEEVGSEEADDEDLDQDFSRRNKKMKTFHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSMSDDDRD ------CCCCCCCCC	27.30	19429919
4	Phosphorylation	----MSMSDDDRDID ----CCCCCCCCCCC	30.49	19429919
14	Phosphorylation	DRDIDIESDEDGDSD CCCCCCCCCCCCCCC	46.78	19429919
20	Phosphorylation	ESDEDGDSDTGLGSS CCCCCCCCCCCCCCC	42.47	19429919
22	Phosphorylation	DEDGDSDTGLGSSRH CCCCCCCCCCCCCCC	37.95	19429919
26	Phosphorylation	DSDTGLGSSRHTNTA CCCCCCCCCCCCCCC	29.28	19429919
27	Phosphorylation	SDTGLGSSRHTNTAN CCCCCCCCCCCCCCC	26.70	19429919
58	Phosphorylation	RRDHIKESFTNLREA HHHHHHHHHHHHHHH	32.16	19429919
60	Phosphorylation	DHIKESFTNLREAVP HHHHHHHHHHHHHCC	42.49	19429919
70	Acetylation	REAVPTLKGEKASRA HHHCCCCCCCHHHHH	68.45	21791702
95	Phosphorylation	QTMRRKISENQKDIE HHHHHHHHHCHHHHH	33.26	22817900
99	Acetylation	RKISENQKDIEEIKR HHHHHCHHHHHHHHH	72.72	21791702
131	Phosphorylation	DQFSEFLSDEEVGSE HHHHHHHCCCCCCCC	48.58	22817900
137	Phosphorylation	LSDEEVGSEEADDED HCCCCCCCCCCCCCC	37.12	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAX_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAX_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAX_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYC_DROME	dm	physical	17898168

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-137, ANDMASS SPECTROMETRY.
PubMed: 18327897