CADE_DROME - dbPTM
CADE_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CADE_DROME
UniProt AC Q24298
Protein Name DE-cadherin
Gene Name shg {ECO:0000312|FlyBase:FBgn0003391}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1507
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Cadherins are calcium-dependent cell adhesion proteins. [PubMed: 7958432 They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types]
Protein Sequence MSTSVQRMSRSYHCINMSATPQAGHLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIPYYTEVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYDDYTTVVIKIEDVNDNPPVFKQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKDIDDIRETIINYEDEGGGERDTDYDLNVLRTQPFYEEKLYKDPHALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDSNVDDDQGWRI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
200PhosphorylationPAFNKARYDESMSEN
CCCCHHHCCHHHCCC		28.9922817900
203PhosphorylationNKARYDESMSENAQP
CHHHCCHHHCCCCCC		25.3922817900
205PhosphorylationARYDESMSENAQPDA
HHCCHHHCCCCCCCC		36.6622817900
317N-linked_GlycosylationYLKENLKNFTHPIAT
CCCHHHCCCCCCHHH		50.65-
466N-linked_GlycosylationTIDPNTGNITALTTF
EECCCCCCEEEEEEE		26.80-
552N-linked_GlycosylationVKAEDEDNASQILYS
EEECCCCCHHHEEEE		39.17-
766N-linked_GlycosylationDDTPGAGNFTFGIDS
CCCCCCCCEEEECCC		32.05-
949N-linked_GlycosylationSGSIRFINVTKEEFI
CCCEEEEEECHHHHC		32.47-
983N-linked_GlycosylationLSLAKLFNTSVSNVD
HHHHHHHCCCCCCCE		41.71-
999N-linked_GlycosylationFTVLQNENHTLDVRF
EEEEECCCCEEEEEE		40.78-
1073N-linked_GlycosylationVPYMIYSNTTSFVGV
CCEEEECCCCCEECC		30.33-
1145N-linked_GlycosylationYEPIAACNNTKISLE
EEEEHHCCCCEEEEE		55.25-
1274N-linked_GlycosylationEQLGRQLNWTHVPNQ
HHHHHHCCCCCCCCC		33.01-
1290N-linked_GlycosylationGFFGCIRNLTINEQT
CCCEEEEEEEECCEE		22.94-
1360UbiquitinationQKNGWHEKDIDDIRE
HHCCCCCCCHHHHHH		47.2831113955
1493PhosphorylationDMYGEEPSDTDSNVD
HHHCCCCCCCCCCCC		57.3222817900
1497PhosphorylationEEPSDTDSNVDDDQG
CCCCCCCCCCCCCCC		40.6222817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CADE_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CADE_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CADE_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARM_DROMEarmgenetic
9774110
ARM_DROMEarmgenetic
16887833
ARM_DROMEarmgenetic
11318874
NOTCH_DROMENgenetic
8598295
MAD_DROMEMadgenetic
17428827
CADN_DROMECadNgenetic
16887833
RHO1_DROMERho1genetic
16207756
RHO1_DROMERho1genetic
16887833
MY61F_DROMEMyo61Fgenetic
22491943
RHOM_DROMErhogenetic
12163402
BRM_DROMEbrmgenetic
11532957
PANG1_DROMEpangenetic
11532957
PANG2_DROMEpangenetic
11532957
CUT_DROMEctgenetic
8598295
PRDX1_DROMEJafrac1genetic
21316590
ARM_DROMEarmphysical
18045836
ARM_DROMEarmphysical
22159415
ARM_DROMEarmphysical
7958432
ARM_DROMEarmphysical
9247265
CTNA_DROMEalpha-Catphysical
7958432
CTNA_DROMEalpha-Catphysical
9247265
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CADE_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1493, AND MASSSPECTROMETRY.

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