dbPTM

OCTB2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OCTB2_DROME
UniProt AC	Q4LBB9
Protein Name	Octopamine receptor beta-2R
Gene Name	Octbeta2R {ECO:0000312\|FlyBase:FBgn0038063}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	536
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. [PubMed: 15998303]
Protein Sequence	MLLCDGLGPEPPRQRHRNRTSAARIRKRPKCCCGDGGSGNQAEQPGGIVSNPISYGQSLTTLARVTAAALTTAAMLHTTNALAATGSSSASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQMVDNL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	N-linked_Glycosylation	PPRQRHRNRTSAARI CCCHHHCCCCHHHHH	45.52	-
92	N-linked_Glycosylation	TGSSSASNSSTGGIA HCCCCCCCCCCCCEE	39.43	-
113	N-linked_Glycosylation	TPATHELNATQPFGG CCCCCCCCCCCCCCC	37.65	-
126	N-linked_Glycosylation	GGSGLNFNESGAGLS CCCCCCCCCCCCCCC	41.26	-
393	Phosphorylation	HEVEQEHTPTKDKHL HHCCCCCCCCCCHHH	31.72	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OCTB2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OCTB2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OCTB2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
OCTB1_DROME	Octbeta1R	genetic	22553037

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OCTB2_DROME

Related Literatures of Post-Translational Modification