H4_XENLA - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H4_XENLA
• UniProt AC: P62799
• Protein Name: Histone H4
• Organism: Xenopus laevis (African clawed frog).
• Sequence Length: 103
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
• Protein Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGRGKGGK ------CCCCCCCCC	36.88	-
2	Acetylation	------MSGRGKGGK ------CCCCCCCCC	36.88	-
4	Citrullination	----MSGRGKGGKGL ----CCCCCCCCCCC	36.02	-
4	Methylation	----MSGRGKGGKGL ----CCCCCCCCCCC	36.02	-
6	Glutarylation	--MSGRGKGGKGLGK --CCCCCCCCCCCCC	64.23	-
6	Acetylation	--MSGRGKGGKGLGK --CCCCCCCCCCCCC	64.23	-
6	Other	--MSGRGKGGKGLGK --CCCCCCCCCCCCC	64.23	-
6	Butyrylation	--MSGRGKGGKGLGK --CCCCCCCCCCCCC	64.23	-
6	Lactoylation	--MSGRGKGGKGLGK --CCCCCCCCCCCCC	64.23	-
9	Propionylation	SGRGKGGKGLGKGGA CCCCCCCCCCCCCHH	60.68	-
9	Acetylation	SGRGKGGKGLGKGGA CCCCCCCCCCCCCHH	60.68	-
9	Lactoylation	SGRGKGGKGLGKGGA CCCCCCCCCCCCCHH	60.68	-
9	Other	SGRGKGGKGLGKGGA CCCCCCCCCCCCCHH	60.68	-
9	Butyrylation	SGRGKGGKGLGKGGA CCCCCCCCCCCCCHH	60.68	-
13	Glutarylation	KGGKGLGKGGAKRHR CCCCCCCCCHHHHHH	60.25	-
13	Lactoylation	KGGKGLGKGGAKRHR CCCCCCCCCHHHHHH	60.25	-
13	Methylation	KGGKGLGKGGAKRHR CCCCCCCCCHHHHHH	60.25	-
13	Butyrylation	KGGKGLGKGGAKRHR CCCCCCCCCHHHHHH	60.25	-
13	Other	KGGKGLGKGGAKRHR CCCCCCCCCHHHHHH	60.25	-
13	Acetylation	KGGKGLGKGGAKRHR CCCCCCCCCHHHHHH	60.25	-
17	Other	GLGKGGAKRHRKVLR CCCCCHHHHHHHHHH	52.60	-
17	Lactoylation	GLGKGGAKRHRKVLR CCCCCHHHHHHHHHH	52.60	-
17	Propionylation	GLGKGGAKRHRKVLR CCCCCHHHHHHHHHH	52.60	-
17	Acetylation	GLGKGGAKRHRKVLR CCCCCHHHHHHHHHH	52.60	-
17	Butyrylation	GLGKGGAKRHRKVLR CCCCCHHHHHHHHHH	52.60	-
21	Methylation	GGAKRHRKVLRDNIQ CHHHHHHHHHHHHCC	39.22	-
32	Propionylation	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
32	Other	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
32	Glutarylation	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
32	Succinylation	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
32	Lactoylation	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
32	Butyrylation	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
32	Acetylation	DNIQGITKPAIRRLA HHCCCCCHHHHHHHH	30.45	-
45	Other	LARRGGVKRISGLIY HHHCCCCCEEECCCH	47.49	-
45	Butyrylation	LARRGGVKRISGLIY HHHCCCCCEEECCCH	47.49	-
45	Propionylation	LARRGGVKRISGLIY HHHCCCCCEEECCCH	47.49	-
48	Phosphorylation	RGGVKRISGLIYEET CCCCCEEECCCHHHH	31.42	-
52	Phosphorylation	KRISGLIYEETRGVL CEEECCCHHHHHHHH	16.86	-
60	Other	EETRGVLKVFLENVI HHHHHHHHHHHHHHH	28.65	-
60	Acetylation	EETRGVLKVFLENVI HHHHHHHHHHHHHHH	28.65	-
60	Glutarylation	EETRGVLKVFLENVI HHHHHHHHHHHHHHH	28.65	-
78	Butyrylation	VTYTEHAKRKTVTAM HHCCHHHCCCEECHH	57.23	-
78	Other	VTYTEHAKRKTVTAM HHCCHHHCCCEECHH	57.23	-
78	Lactoylation	VTYTEHAKRKTVTAM HHCCHHHCCCEECHH	57.23	-
78	Glutarylation	VTYTEHAKRKTVTAM HHCCHHHCCCEECHH	57.23	-
78	Succinylation	VTYTEHAKRKTVTAM HHCCHHHCCCEECHH	57.23	-
78	Propionylation	VTYTEHAKRKTVTAM HHCCHHHCCCEECHH	57.23	-
80	Propionylation	YTEHAKRKTVTAMDV CCHHHCCCEECHHHH	46.79	-
80	Acetylation	YTEHAKRKTVTAMDV CCHHHCCCEECHHHH	46.79	-
80	Other	YTEHAKRKTVTAMDV CCHHHCCCEECHHHH	46.79	-
80	Butyrylation	YTEHAKRKTVTAMDV CCHHHCCCEECHHHH	46.79	-
80	Glutarylation	YTEHAKRKTVTAMDV CCHHHCCCEECHHHH	46.79	-
89	Phosphorylation	VTAMDVVYALKRQGR ECHHHHHHHHHHCCC	13.18	-
92	Acetylation	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-
92	Succinylation	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-
92	Propionylation	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-
92	Other	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-
92	Lactoylation	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-
92	Glutarylation	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-
92	Butyrylation	MDVVYALKRQGRTLY HHHHHHHHHCCCCEE	34.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
48	S	Phosphorylation	Kinase	PAK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H4_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H4_XENLA !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H4_XENLA	hist1h4a	physical	23178455

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.