USP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USP_DROME
• UniProt AC: P20153
• Protein Name: Protein ultraspiracle
• Gene Name: usp
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 508
• Subcellular Localization: Nucleus.
• Protein Description: Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene..
• Protein Sequence: MDNCDQDASFRLSHIKEEVKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLEAPPPPGLAMKLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	QLNDSNNSSFSPKAE HCCCCCCCCCCCCCC	36.69	19429919
33	Phosphorylation	LNDSNNSSFSPKAES CCCCCCCCCCCCCCC	31.69	19429919
35	Phosphorylation	DSNNSSFSPKAESPV CCCCCCCCCCCCCCC	27.69	19429919
356	Phosphorylation	DGSFERRSPGLQPQQ CCCCCCCCCCCCHHH	29.55	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIG_DROME	rig	physical	14645129
TRR_DROME	trr	physical	14603321
FOXO_DROME	foxo	genetic	25421296
USP_DROME	usp	physical	18771703
USP_DROME	usp	physical	18980211
MED15_DROME	MED15	physical	26222308
HR38_DROME	Hr38	physical	7644522
ECR_DROME	EcR	physical	25242320
ECR_DROME	EcR	physical	26222308
ECR_DROME	EcR	physical	17956872
ECR_DROME	EcR	physical	1327536
ECR_DROME	EcR	physical	7644522
ECR_DROME	EcR	physical	8247157
ECR_DROME	EcR	physical	18771703
ECR_DROME	EcR	physical	14594447
ECR_DROME	EcR	physical	14977043
ECR_DROME	EcR	physical	18980211
ECR_DROME	EcR	physical	8524239
RIG_DROME	rig	physical	26222308
MED16_DROME	MED16	physical	26222308
MED23_DROME	MED23	physical	26222308
MED14_DROME	MED14	physical	26222308
MED30_DROME	MED30	physical	26222308
CDK8_DROME	Cdk8	physical	26222308
MED1_DROME	MED1	physical	26222308
FOXO_DROME	foxo	physical	25421296
CCNC_DROME	CycC	physical	26222308
HSP7D_DROME	Hsc70-4	physical	26222308
FKB39_DROME	FK506-bp1	physical	17956872
MED17_DROME	MED17	physical	26222308
MED25_DROME	MED25	physical	26222308
MED13_DROME	skd	physical	26222308
MED12_DROME	kto	physical	26222308

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, AND MASSSPECTROMETRY.
PubMed: 18327897