CIC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIC_DROME
• UniProt AC: Q9U1H0
• Protein Name: Putative transcription factor capicua
• Gene Name: cic
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1832
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor required for the specification of numerous cell types during embryonic development. Required for terminal patterning of early embryos. May associate with gro to repress tll and hkb, restricting their expression to embryonic terminal poles where they initiate correct development of head and tail structures. Required for dorsoventral patterning of oocytes and early embryos. Cooperates with dl to repress zen and other dorsal specific genes within the embryo and promotes expression of the ventralizing factor pip in ovarian follicle cells. Required during wing development for the specification of intervein areas, where it mediates localized repression of vein specific genes such as aos, dpp and vvl..
• Protein Sequence: MNAFQDFELGAKLYLQCLLSLSSSRSATPSYTSPVNHAGASPLNAIAHSPVNVSATHRQNFFTPIANQSQQQQQQQPVAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGSNSNTHVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSAPPTSGSSSSHNSVGHATSVIRISSSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVASMSQDKMLAKNGYNAPWFKLLPHMTPMSKASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQKQQQEEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTPFQPTGGAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASGGGVVSAPPPNSGSVGAIFNFNVPTATALSQKQFHYPMHHPHRSPTDLRDEEADREEITQGTKSGESSEKDKPALDDQERDEVEEEDEDEEDDDEDDEDDEQFMQELASVNASAGFDDLVPYAMPKVVITPTPTPPPVATIVTPIKRKQFTIVRSLTPLQPSNSPHQQLKHLHQRRGETPPTVITRVPTPTINHFTIIRTQQHPHTHPHNTPPPLFFKQKVQGSPVIATVTTSTLSSSSSNPANNEAPNKFSNFPTQHQPTTTTTISCNTNNNATPIIRKLLTLQEGAELGGSHKGTGRAAILYDALVLDTLHGQDEEEEEDEGNAEKQENPKVAGKEQVTTSQPATMLLITDVNAYNQQHVAGNAATPVSGAATLRPVSFISINACNKITLPANARILTAATATSTAAGAAVTSQAGATLTVMTKASAATNHSSSNASDITITAASAAPVPTSGSSIVMINSTTNPSTSSNSTSCSAAAHQACVPSSPAGMGLGHAANIATPPASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGGYTLRNHNGLSSLPPPVSAQPTMLLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAPPERGMDGGMSGCASAAASGGDESDIDADGQQFILAPTPAQLGRAPLQRRKNLSQSKSESNVSFGANLGASNGQHISRKLHSPTMMESSSPIIGHVNSSNLSSALPTPTSSTTTPNSDEQLPLTPTTSSSNSNLNQQQPKSPMKGAPGSTAAALKKKNDEMNNSVLKQVDFEKKYKALPQFQPEDCQSPSAIAVPSSPRVYGTNYRKKNTAPPPVQKLMCEDDSIDEPASAPPTTTQRFFGPDFNNELKELESSDQTGRSPRTPKTPLQSARSDASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSKHSDVFPRKQDLQLKIREVRQKLLGQASCTPHSAGPNTPSDSNSSSTTLSASSTSLNMQTTSAADVFQYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	PVNHAGASPLNAIAH CCCCCCCCCCCHHHC	29.06	18327897
49	Phosphorylation	PLNAIAHSPVNVSAT CCCHHHCCCCCCCCH	22.86	18327897
567	Phosphorylation	CSKDRRKSSTSTATP CCCCCCCCCCCCCCC	36.72	19429919
568	Phosphorylation	SKDRRKSSTSTATPG CCCCCCCCCCCCCCC	29.43	19429919
569	Phosphorylation	KDRRKSSTSTATPGG CCCCCCCCCCCCCCC	36.87	19429919
570	Phosphorylation	DRRKSSTSTATPGGK CCCCCCCCCCCCCCC	20.28	19429919
571	Phosphorylation	RRKSSTSTATPGGKA CCCCCCCCCCCCCCC	34.34	19429919
573	Phosphorylation	KSSTSTATPGGKASG CCCCCCCCCCCCCCC	23.66	19429919
796	Phosphorylation	AFKSMPISPKGSGGK CCCCCCCCCCCCCCC	18.06	27626673
1287	Phosphorylation	ITAASAAPVPTSGSS EEECEECCCCCCCCE	32.13	18327897
1638	Phosphorylation	FQPEDCQSPSAIAVP CCCCCCCCCCEEECC	27.44	29892262
1647	Phosphorylation	SAIAVPSSPRVYGTN CEEECCCCCCCCCCC	15.62	29892262
1716	Phosphorylation	RSPRTPKTPLQSARS CCCCCCCCCCHHHCC	30.36	10652276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CIC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERKA_DROME	rl	physical	17255944
MK01_HUMAN	MAPK1	physical	17255944
ERKA_DROME	rl	physical	26124095
GROU_DROME	gro	physical	10652276

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-49 AND THR-1716,AND MASS SPECTROMETRY.
PubMed: 18327897