U518_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U518_DROME
• UniProt AC: Q9VQK0
• Protein Name: UPF0518 protein CG3558
• Gene Name: CG3558
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1041
• Protein Sequence: MWLRQSSGGGVASVGHVGPLRQRPIDAATDCDPRACYDSFCKHWQQAFEIIQHSAPPSHDDVLGVVSHLDYMVTLLLVELHHCNKVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGRYANAVRLEQLKLYELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFPPDLEKRLVILLNQLCVVLMQNVHLLDLFFFSAQTQVQEQILNGNVAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSNIGTYIAQYSSICPLLVTGLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALEFCNAVVQVAHEMIKQQLLDFMYQGFIVPVLGPAILQTNIDSQISAMSYLDLILRSITEPGLLRAFVRFLLDTEKFDGERILDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKFMLPGKHVPISHRHKINKIDPYLNSSEFFLELSPDVMKRARDLARPKSVHEPVVSELTPLPSLPSPVMSKTIGANWNYYGVHTGDSLYANIQAYLFEAHWRIAQCQKDCLKWANSYRYQKWPRHGQGRVHAHALELARQFFSEFGGGPIAANETGEKQLDSLQSIGESSGYESFKWRPADEESEATDTTVATTASEADMDHNSSSLSSVLGASGKRESWRTSNSNRNELILTDLDFSEDLFAQGTVSLGPFLNAIWGKLQTFTSNSLYVNLHLTGLITRLAWYPLPLIHSLLLRSDIAITSDTPSFHQVLRILKQQIDAELPVTEDSLEIIDVARSSLIDREFRLANARKGNEGSPMHHSQQQQMVTNSGQQQGQLRSAYATLSAATPVQATPTSAYDPFKRSDNKRRSISKSITSMFSRKSASTSTAPPNGSSASSGLSQIYAFFTGAASNLVGNNASNDGRGISQAQTSAGTCETSLSTQPPAGASRTGANATSTAASGSNSSIAGSTLTLSAQSNTTTHSASTLHGLDGGPSTGGFNSEPASLDSVASMGIIASTSGTERSRDLALCAVLMDEWLKELAAIAQEQSVVLVTEQGSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
490	Phosphorylation	RDLARPKSVHEPVVS HHHCCCCCCCCCCCC	31.24	19429919
497	Phosphorylation	SVHEPVVSELTPLPS CCCCCCCCCCCCCCC	27.42	19429919
504	Phosphorylation	SELTPLPSLPSPVMS CCCCCCCCCCCCCCC	61.67	19429919
507	Phosphorylation	TPLPSLPSPVMSKTI CCCCCCCCCCCCCCC	35.11	19429919
511	Phosphorylation	SLPSPVMSKTIGANW CCCCCCCCCCCCCCC	27.21	19429919
603	Phosphorylation	TGEKQLDSLQSIGES CCHHHHHHHHHHHHC	36.58	19429919
606	Phosphorylation	KQLDSLQSIGESSGY HHHHHHHHHHHCCCC	37.54	19429919
797	Phosphorylation	ARKGNEGSPMHHSQQ CCCCCCCCCCCHHHC	16.93	12537569
822	Phosphorylation	QGQLRSAYATLSAAT HHHHHHHHHHHHCCC	11.02	18281928
839	Phosphorylation	QATPTSAYDPFKRSD CCCCCCCCCCCCCCC	24.74	18281928
855	Phosphorylation	KRRSISKSITSMFSR CCCCHHHHHHHHHHC	25.06	19429919
857	Phosphorylation	RSISKSITSMFSRKS CCHHHHHHHHHHCCC	22.64	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U518_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U518_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U518_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC12_DROME	Ubc12	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490 AND SER-797, ANDMASS SPECTROMETRY.
PubMed: 18327897